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Gene Family: Cystatin superfamily

Also known as : "cysteine proteinase inhibitors", "cysteine protease inhibitors"

Cystatin: The cystatins are a family of cysteine protease inhibitors which share a sequence homology and a common tertiary structure of an alpha helix lying on top of an anti-parallel beta strand. The family is subdivided as described below. Cystatins show similarity to fetuins, kininogens, histidine-rich glycoproteins and cystatin-related proteins. Cystatins mainly inhibit peptidase enzymes (another term for proteases) belonging to peptidase families C1 (papain family) and C13 (legumain family). They are known to mis-fold to form amyloid deposits and are implicated in several diseases. [Source: Wikipedia]

Family contains the following subsets

Genes contained within subsets