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Gene Family: Caspase recruitment domain containing (CARD)

CARD domain: Caspase recruitment domains, or Caspase activation and recruitment domains ( CARDs ), are interaction motifs found in a wide array of proteins, typically those involved in processes relating to inflammation and apoptosis. These domains mediate the formation of larger protein complexes via direct interactions between individual CARDs. CARD domains are found on a strikingly wide range of proteins, including helicases, kinases, mitochondrial proteins, caspases, and other cytoplasmic factors. [Source: Wikipedia]

Genes contained within the family: 30

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
APAF1 apoptotic peptidase activating factor 1 CED4, APAF-1 12q23.1
BCL10 B-cell CLL/lymphoma 10 CARMEN, CIPER, mE10, c-E10, CLAP 1p22.3
BIRC2 baculoviral IAP repeat containing 2 API1 cIAP1, hiap-2, MIHB, RNF48, c-IAP1 11q22.2
BIRC3 baculoviral IAP repeat containing 3 API2 cIAP2, hiap-1, MIHC, RNF49, MALT2, c-IAP2 11q22.2
NOL3 nucleolar protein 3 MYP, NOP30, ARC, CARD2 16q22.1
RIPK2 receptor interacting serine/threonine kinase 2 RIP2, RICK, CARDIAK, CARD3 8q21.3
NOD1 nucleotide binding oligomerization domain containing 1 CARD4 NLRC1, CLR7.1 7p14.3
PYCARD PYD and CARD domain containing TMS-1, ASC, CARD5 16p11.2
CARD6 caspase recruitment domain family member 6 CINCIN1 5p13.1
NLRP1 NLR family pyrin domain containing 1 NALP1, SLEV1 NAC, CARD7, DKFZp586O1822, KIAA0926, VAMAS1, DEFCAP, CLR17.1 17p13
CARD8 caspase recruitment domain family member 8 TUCAN, KIAA0955, CARDINAL, NDPP, Dakar 19q13.33
CARD9 caspase recruitment domain family member 9 9q34.3
CARD10 caspase recruitment domain family member 10 CARMA3, BIMP1 22q13.1
CARD11 caspase recruitment domain family member 11 CARMA1, BIMP3 7p22.2
NLRC4 NLR family CARD domain containing 4 CARD12 CLAN1, ipaf, CLANA, CLANB, CLANC, CLAND, CLR2.1, CLAN 2p22.3
CRADD CASP2 and RIPK1 domain containing adaptor with death domain RAIDD 12q22
CARD14 caspase recruitment domain family member 14 PSORS2 CARMA2, BIMP2 17q25.3
NOD2 nucleotide binding oligomerization domain containing 2 CARD15, IBD1 BLAU, CD, PSORAS1, CLR16.3, NLRC2 16q12.1
CARD16 caspase recruitment domain family member 16 COP1, COP, PSEUDO-ICE 11q22.3
CARD17 caspase recruitment domain family member 17 INCA 11q22.3
CARD18 caspase recruitment domain family member 18 UNQ5804, ICEBERG, pseudo-ICE 11q22.3
CARD19 caspase recruitment domain family member 19 C9orf89 MGC11115, bA370F5.1, BinCARD 9q22.31
MAVS mitochondrial antiviral signaling protein VISA, KIAA1271, IPS-1, Cardif 20p13
IFIH1 interferon induced with helicase C domain 1 MDA-5, Hlcd, MDA5, IDDM19 2q24.2
CASP1 caspase 1 IL1BC ICE 11q22.3
CASP2 caspase 2 NEDD2 ICH1, PPP1R57, MGC2181 7q34
CASP4 caspase 4 ICE(rel)II, ICH-2, TX 11q22.3
CASP5 caspase 5 ICE(rel)III 11q22.3
CASP9 caspase 9 MCH6, ICE-LAP6, APAF-3, PPP1R56 1p36.21
CASP12 caspase 12 (gene/pseudogene) CASP12P1 11q22.3