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Gene Family: Peroxiredoxins (PRDX)

Peroxiredoxin: Peroxiredoxins (Prxs, EC 1.11.1.15 ) are a ubiquitous family of antioxidant enzymes that also control cytokine -induced peroxide levels and thereby mediate signal transduction in mammalian cells. The physiological importance of peroxiredoxins is illustrated by their relative abundance (one of the most abundant proteins in erythrocytes after hemoglobin is peroxiredoxin 2). [Source: Wikipedia]

Genes contained within the family: 6

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
PRDX1 peroxiredoxin 1 PAGA NKEFA 1p34.1
PRDX2 peroxiredoxin 2 TDPX1 PRP, NKEFB, TSA, PRXII, PRX2, MGC4104 19p13.13
PRDX3 peroxiredoxin 3 AOP1 MER5, AOP-1, SP-22 10q26.11
PRDX4 peroxiredoxin 4 AOE37-2 Xp22.11
PRDX5 peroxiredoxin 5 ACR1, AOEB166, MGC142285, PRXV, PMP20, B166, PRDX6, PLP, SBBI10, MGC117264, MGC142283 11q13.1
PRDX6 peroxiredoxin 6 AOP2, KIAA0106, 1-Cys, NSGPx, PRX, aiPLA2, MGC46173, p29 1q25.1