Skip to Navigation
New Beta Site!

Please view this page on our new HGNC beta site and let us know what you think via the feedback form.

Gene Family: Actins (ACT)

Actin: Actins are globular multi-functional proteins that form microfilaments. An actin protein's mass is roughly 42- kDa and they are the monomeric subunit of two types of filaments in cells: microfilaments, one of the three major components of the cytoskeleton, and thin filaments, part of the contractile apparatus in muscle cells. They can be present as either a free monomer called G-actin (globular) or as part of a linear polymer microfilament called F-actin (filamentous) both of which are essential for such important cellular functions as the mobility and contraction of cells during cell division. Actins participate in many important cellular processes, including muscle contraction, cell motility, cell division and cytokinesis, vesicle and organelle movement, cell signaling, and the establishment and maintenance of cell junctions and cell shape. Many of these processes are mediated by extensive and intimate interactions of actin with cellular membranes. In vertebrates, three main groups of actin isoforms, alpha, beta, and gamma have been identified. The alpha actins, found in muscle tissues, are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton, and as mediators of internal cell motility. [Source: Wikipedia]

Genes contained within the family: 6

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
ACTA1 actin, alpha 1, skeletal muscle ACTA NEM3 1q42.13
ACTA2 actin, alpha 2, smooth muscle, aorta ACTSA 10q23.31
ACTB actin beta 7p22.1
ACTC1 actin, alpha, cardiac muscle 1 ACTC CMD1R 15q14
ACTG1 actin gamma 1 ACTG, DFNA20, DFNA26 17q25.3
ACTG2 actin, gamma 2, smooth muscle, enteric ACTL3, ACTA3 ACTSG 2p13.1

External resources