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Gene Family: Zinc fingers ZZ-type (ZZZ)

A subset of : Zinc fingers

ZZ zinc finger: In molecular biology the ZZ-type zinc finger domain is a type of protein domain that was named because of its ability to bind two z inc ions. These domains contain 4-6 Cys residues that participate in zinc binding (plus additional Ser/His residues), including a Cys-X2-Cys motif found in other zinc finger domains. These zinc fingers are thought to be involved in protein-protein interactions. The structure of the ZZ domain shows that it belongs to the family of cross-brace zinc finger motifs that include the PHD, RING, and FYVE domains. [Source: Wikipedia]

Genes contained within the family: 18

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
CREBBP CREB binding protein RSTS RTS, CBP, KAT3A 16p13.3
DMD dystrophin MRX85 BMD, DXS142, DXS164, DXS206, DXS230, DXS239, DXS268, DXS269, DXS270, DXS272 Xp21.2-p21.1
DRP2 dystrophin related protein 2 Xq22.1
DTNA dystrobrevin alpha D18S892E, DTN, DTN-1, DTN-2, DTN-3, DRP3 18q12.1
DTNB dystrobrevin beta 2p23.3
DYTN dystrotelin 2q33.3
EP300 E1A binding protein p300 p300, KAT3B 22q13.2
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 jdf2, p528, D15F37S1 15q13.1
NBR1 NBR1, autophagy cargo receptor M17S2 CA125, KIAA0049, 1A1-3B 17q21.31
SQSTM1 sequestosome 1 PDB3, OSIL p62, p60, p62B, A170 5q35.3
TADA2B transcriptional adaptor 2B MGC21874 4p16.1
UTRN utrophin DMDL DRP, DRP1 6q24.2
KCMF1 potassium channel modulatory factor 1 ZZZ1, PCMF, DEBT91, DKFZP434L1021 2p11.2
ZSWIM2 zinc finger SWIM-type containing 2 ZZZ2, MEX, MGC33890 2q32.1
ZZZ3 zinc finger ZZ-type containing 3 DKFZP564I052, ATAC1 1p31.1
ZZEF1 zinc finger ZZ-type and EF-hand domain containing 1 FLJ10821, ZZZ4, KIAA0399 17p13.2
MIB2 mindbomb E3 ubiquitin protein ligase 2 ZZANK1 ZZZ5, skeletrophin, FLJ39787 1p36.33
MIB1 mindbomb E3 ubiquitin protein ligase 1 ZZZ6, KIAA1323, DIP-1, MIB, ZZANK2 18q11.2