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Gene Family: Tissue inhibitor of metallopeptidases (TIMP)

Also known as : "TIMPs", "tissue inhibitor of metalloproteinases"

Tissue inhibitor of metalloproteinase: The matrix metalloproteinases are inhibited by specific endogenous tissue inhibitors of metalloproteinases (TIMPs), which comprise a family of four protease inhibitors: TIMP1, TIMP2, TIMP3 and TIMP4. Overall, all MMPs are inhibited by TIMPs once they are activated but the gelatinases (MMP-2 and MMP- ) can form complexes with TIMPs when the enzymes are in the latent form. The complex of latent MMP-2 (pro-MMP-2)with TIMP-2 serves to facilitate the activation of pro-MMP-2 at the cell surface by MT1-MMP ( MMP-14 ), a membrane-anchored MMP. The role of the pro-MMP-9/TIMP-1 complex is still unknown. [Source: Wikipedia]

Genes contained within the family: 4

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
TIMP1 TIMP metallopeptidase inhibitor 1 TIMP, CLGI EPO Xp11.3
TIMP2 TIMP metallopeptidase inhibitor 2 CSC-21K 17q25.3
TIMP3 TIMP metallopeptidase inhibitor 3 SFD 22q12.3
TIMP4 TIMP metallopeptidase inhibitor 4 3p25.2

Publications

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