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Gene Family: Selenoproteins (SELENO)

Selenoproteins: In molecular biology a selenoprotein is any protein that includes a selenocysteine (Se-Cys) amino acid residue. Among functionally characterized selenoproteins are five glutathione peroxidases (GPX) and three thioredoxin reductases, (TrxR/TXNRD) which both contain only one Se-Cys. Selenoprotein P is the most common selenoprotein found in the plasma. It is unusual because in humans it contains 10 Se-Cys residues, which are split into two domains, a longer N-terminal domain that contains 1 Se-Cys, and a shorter C-terminal domain that contains 9 Se-Cys. The longer N-terminal domain is likely an enzymatic domain, and the shorter C-terminal domain is likely a means of safely transporting the very reactive selenium atom throughout the body. [Source: Wikipedia]

Genes contained within the family: 25

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
DIO1 iodothyronine deiodinase 1 TXDI1 1p32.3
DIO3 iodothyronine deiodinase 3 TXDI3 14q32.31
GPX1 glutathione peroxidase 1 3p21.31
GPX2 glutathione peroxidase 2 GSHPX-GI 14q23.3
GPX3 glutathione peroxidase 3 5q33.1
GPX4 glutathione peroxidase 4 PHGPx, MCSP 19p13.3
GPX6 glutathione peroxidase 6 GPXP3 6p22.1
SELENOF selenoprotein F SEP15 1p22.3
SELENOH selenoprotein H C11orf31 SELH 11q12.1
SELENOI selenoprotein I EPT1 KIAA1724, SELI, SEPI 2p23.3
SELENOK selenoprotein K SELK 3p21.1
SELENOM selenoprotein M SELM, SEPM 22q12.2
SELENON selenoprotein N RSMD1, MDRS1, SEPN1 SELN, RSS 1p36.11
SELENOO selenoprotein O SELO 22q13.33
SELENOP selenoprotein P SEPP1 SeP, SELP, SEPP 5p12
MSRB1 methionine sulfoxide reductase B1 SEPX1 SelR, SepR, SelX 16p13.3
SELENOS selenoprotein S VIMP SELS, MGC2553, SBBI8, AD-015, SEPS1 15q26.3
SELENOT selenoprotein T SELT 3q25.1
SELENOV selenoprotein V SELV 19q13.2
SELENOW selenoprotein W SEPW1 SELW 19q13.33
DIO2 iodothyronine deiodinase 2 TXDI2, SelY 14q31.1
SEPHS2 selenophosphate synthetase 2 SPS2, SPS2b 16p11.2
TXNRD1 thioredoxin reductase 1 TXNR, GRIM-12, Trxr1 12q23.3
TXNRD2 thioredoxin reductase 2 TR, TRXR2, TR3 22q11.21
TXNRD3 thioredoxin reductase 3 TR2, TRXR3, TGR 3q21.3

Publications

27645994, 12775843