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Gene Family: PHD finger proteins (PHF)

Also known as : "Zinc fingers, PHD-type", "PHD zinc fingers"
A subset of : Zinc fingers

PHD finger: The PHD finger was discovered in 1993 as a Cys 4 -His-Cys 3 motif in the plant homeodomain (hence PHD) proteins HAT3.1 in Arabidopsis thaliana and maize ZmHox1a. The PHD finger motif resembles the metal binding RING domain (Cys 3 -His-Cys 4 ) and FYVE domain. It occurs as a single finger, but often in clusters of two or three, and it also occurs together with other domains, such as the chromodomain and the bromodomain. [Source: Wikipedia]

Genes contained within the family: 90

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
AIRE autoimmune regulator APECED PGA1, APS1 21q22.3
ASH1L ASH1 like histone lysine methyltransferase huASH1, ASH1, ASH1L1, KMT2H 1q22
ASH2L ASH2 like histone lysine methyltransferase complex subunit ASH2L1 ASH2L2, ASH2, Bre2 8p11.23
BAZ1A bromodomain adjacent to zinc finger domain 1A hACF1, ACF1, WALp1, WCRF180 14q13.1-q13.2
BAZ1B bromodomain adjacent to zinc finger domain 1B WBSCR9, WBSCR10 WSTF 7q11.23
BAZ2A bromodomain adjacent to zinc finger domain 2A KIAA0314, TIP5, WALp3 12q13.3
BAZ2B bromodomain adjacent to zinc finger domain 2B WALp4 2q24.2
BPTF bromodomain PHD finger transcription factor FALZ FAC1, NURF301 17q24.2
BRD1 bromodomain containing 1 BRL, BRPF2 22q13.33
BRPF1 bromodomain and PHD finger containing 1 BR140 3p25.3
BRPF3 bromodomain and PHD finger containing 3 KIAA1286 6p21.31
CHD3 chromodomain helicase DNA binding protein 3 Mi-2a, ZFH, Mi2-ALPHA 17p13.1
CHD4 chromodomain helicase DNA binding protein 4 Mi-2b, Mi2-BETA 12p13.31
CHD5 chromodomain helicase DNA binding protein 5 1p36.31
CXXC1 CXXC finger protein 1 HsT2645, PCCX1, hCGBP, PHF18, CGBP, SPP1, CFP1, ZCGPC1 18q21.1
DIDO1 death inducer-obliterator 1 C20orf158, DATF1 DIO1, dJ885L7.8, FLJ11265, KIAA0333, DIO-1, BYE1 20q13.33
DPF1 double PHD fingers 1 neuro-d4, NEUD4, BAF45b 19q13.2
DPF2 double PHD fingers 2 REQ ubi-d4, BAF45d 11q13.1
DPF3 double PHD fingers 3 cer-d4, Cerd4, FLJ14079, BAF45c 14q24.2
FBXL19 F-box and leucine rich repeat protein 19 DKFZp434K0410, Fbl19, JHDM1C, CXXC11 16p11.2
ING1 inhibitor of growth family member 1 p33ING1, p33ING1b, p24ING1c, p33, p47, p47ING1a 13q34
ING2 inhibitor of growth family member 2 ING1L p33ING2 4q35.1
ING3 inhibitor of growth family member 3 p47ING3, FLJ20089, Eaf4, MEAF4 7q31.31
ING4 inhibitor of growth family member 4 p29ING4, my036 12p13.31
ING5 inhibitor of growth family member 5 FLJ23842, p28ING5 2q37.3
KAT6A lysine acetyltransferase 6A ZNF220, RUNXBP2, MYST3 MOZ, ZC2HC6A 8p11.21
KAT6B lysine acetyltransferase 6B MYST4 querkopf, qkf, Morf, MOZ2, ZC2HC6B 10q22.2
KDM2A lysine demethylase 2A FBXL11 KIAA1004, FBL11, LILINA, DKFZP434M1735, FBL7, FLJ00115, CXXC8, JHDM1A 11q13.2
KDM2B lysine demethylase 2B FBXL10 PCCX2, CXXC2, Fbl10, JHDM1B 12q24.31
KDM5A lysine demethylase 5A RBBP2, JARID1A 12p13.33
KDM5B lysine demethylase 5B JARID1B RBBP2H1A, PLU-1, CT31, PPP1R98 1q32.1
KDM5C lysine demethylase 5C SMCX, JARID1C, MRX13 DXS1272E, XE169 Xp11.22
KDM5D lysine demethylase 5D HYA, HY, SMCY, JARID1D KIAA0234 Yq11.223
KDM7A lysine demethylase 7A JHDM1D KIAA1718 7q34
KMT2A lysine methyltransferase 2A MLL TRX1, HRX, ALL-1, HTRX1, CXXC7, MLL1A 11q23.3
KMT2B lysine methyltransferase 2B KIAA0304, MLL2, TRX2, HRX2, WBP7, MLL1B, MLL4, CXXC10 19q13.12
KMT2C lysine methyltransferase 2C MLL3 KIAA1506, HALR 7q36.1
KMT2D lysine methyltransferase 2D TNRC21, MLL2 ALR, MLL4, CAGL114 12q13.12
KMT2E lysine methyltransferase 2E MLL5 HDCMC04P 7q22.3
MLLT6 MLLT6, PHD finger containing AF17, FLJ23480 17q12
MLLT10 MLLT10, histone lysine methyltransferase DOT1L cofactor AF10 10p12.31
MTF2 metal response element binding transcription factor 2 M96, PCL2, TDRD19A 1p22.1
NFX1 nuclear transcription factor, X-box binding 1 NFX2, MGC20369, Tex42, TEG-42 9p12
NSD1 nuclear receptor binding SET domain protein 1 STO ARA267, FLJ22263, KMT3B 5q35.3
PHF1 PHD finger protein 1 MTF2L2, TDRD19C, PCL1 6p21.32
PHF2 PHD finger protein 2 KIAA0662, JHDM1E, CENP-35, KDM7C 9q22.31
PHF3 PHD finger protein 3 6q12
PHF5A PHD finger protein 5A MGC1346, SF3b14b, INI, bK223H9.2, Rds3, SAP14b, SF3B7 22q13.2
PHF6 PHD finger protein 6 BFLS, BORJ KIAA1823, MGC14797, CENP-31 Xq26.2
PHF7 PHD finger protein 7 NYD-SP6, HSPC226 3p21.1
G2E3 G2/M-phase specific E3 ubiquitin protein ligase KIAA1333 PHF7B, FLJ20333 14q12
PHF8 PHD finger protein 8 ZNF422, KIAA1111, JHDM1F, KDM7B Xp11.22
FANCL Fanconi anemia complementation group L PHF9 FLJ10335, FAAP43, Pog 2p16.1
PHF10 PHD finger protein 10 FLJ10975, XAP135, BAF45a 6q27
PHF11 PHD finger protein 11 NY-REN-34, BCAP, IGER 13q14.2
PHF12 PHD finger protein 12 PF1, KIAA1523 17q11.2
PHF13 PHD finger protein 13 MGC43399 1p36.31
PHF14 PHD finger protein 14 KIAA0783 7p21.3
JADE2 jade family PHD finger 2 PHF15 KIAA0239, JADE-2 5q31.1
JADE3 jade family PHD finger 3 PHF16 KIAA0215, JADE-3 Xp11.3
JADE1 jade family PHD finger 1 PHF17 JADE-1 4q28.2
PHF19 PHD finger protein 19 DKFZP727G051, PCL3, MTF2L1, TDRD19B 9q33.2
PHF20 PHD finger protein 20 C20orf104 dJ1121G12.1, TDRD20A 20q11.22-q11.23
PHF20L1 PHD finger protein 20 like 1 CGI-72, FLJ13649, MGC64923, FLJ21615, TDRD20B 8q24.22
PHF21A PHD finger protein 21A BHC80, KIAA1696, BM-006 11p11.2
PHF21B PHD finger protein 21B PHF4 BHC80L, FLJ34161 22q13.31
INTS12 integrator complex subunit 12 PHF22 SBBI22, INT12 4q24
PHF23 PHD finger protein 23 MGC2941, FLJ16355 17p13.1
PHF24 PHD finger protein 24 KIAA1045 9p13.3
PHRF1 PHD and ring finger domains 1 RNF221 KIAA1542, PPP1R125 11p15.5
PYGO1 pygopus family PHD finger 1 15q21.3
PYGO2 pygopus family PHD finger 2 1q21.3
RSF1 remodeling and spacing factor 1 HBXAP XAP8, RSF-1, p325 11q14.1
SHPRH SNF2 histone linker PHD RING helicase FLJ90837, KIAA2023, bA545I5.2 6q24.3
SP100 SP100 nuclear antigen 2q37.1
SP110 SP110 nuclear body protein IFI41, IFI75 2q37.1
SP140 SP140 nuclear body protein LYSP100-B, LYSP100-A 2q37.1
SP140L SP140 nuclear body protein like 2q37.1
TAF3 TATA-box binding protein associated factor 3 TAF140, TAFII140 10p14
TCF19 transcription factor 19 SC1 6p21.33
TRIM24 tripartite motif containing 24 TIF1 hTIF1, Tif1a, RNF82, TIF1A 7q33-q34
TRIM28 tripartite motif containing 28 TIF1B, KAP1, TF1B, RNF96, PPP1R157 19q13.4
TRIM33 tripartite motif containing 33 TIF1GAMMA, FLJ11429, KIAA1113, TIFGAMMA, RFG7, TF1G, TIF1G, PTC7 1p13.2
TRIM66 tripartite motif containing 66 C11orf29 KIAA0298, TIF1D 11p15.4
UHRF1 ubiquitin like with PHD and ring finger domains 1 ICBP90, Np95, FLJ21925, RNF106, TDRD22 19p13.3
UHRF2 ubiquitin like with PHD and ring finger domains 2 RNF107, NIRF, URF2, MGC33463, TDRD23 9p24.1
NSD2 nuclear receptor binding SET domain protein 2 WHSC1 MMSET, KMT3G 4p16.3
NSD3 nuclear receptor binding SET domain protein 3 WHSC1L1 FLJ20353, WHISTLE, KMT3F 8p11.23
ZMYND8 zinc finger MYND-type containing 8 PRKCBP1 RACK7 20q13.12
ZMYND11 zinc finger MYND-type containing 11 BS69 10p15.3