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Gene Family: Histones

Histone: In biology, histones are highly alkaline proteins found in eukaryotic cell nuclei that package and order the DNA into structural units called nucleosomes. They are the chief protein components of chromatin, acting as spools around which DNA winds, and play a role in gene regulation. Without histones, the unwound DNA in chromosomes would be very long (a length to width ratio of more than 10 million to 1 in human DNA). For example, each human cell has about 1.8 meters of DNA, (~6 ft) but wound on the histones it has about 90 micrometers (0.09 mm) of chromatin, which, when duplicated and condensed during mitosis, result in about 120 micrometers of chromosomes. [Source: Wikipedia]

Genes contained within the family: 116

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
HIST1H1A histone cluster 1 H1 family member a H1F1 H1.1, H1a 6p22.2
HIST1H1B histone cluster 1 H1 family member b H1F5 H1.5, H1b, H1s-3 6p22.1
HIST1H1C histone cluster 1 H1 family member c H1F2 H1.2, H1s-1, H1c 6p22.2
HIST1H1D histone cluster 1 H1 family member d H1F3 H1.3, H1d, H1s-2 6p22.2
HIST1H1E histone cluster 1 H1 family member e H1F4 H1.4, H1e, H1s-4 6p22.2
HIST1H1PS1 histone cluster 1 H1 pseudogene 1 dJ34B20.16, FLJ39701, H1F6P 6p22.2
HIST1H1PS2 histone cluster 1 H1 pseudogene 2 H3FEP pH3/e 6p22.2
HIST1H1T histone cluster 1 H1 family member t H1FT H1t 6p22.2
HIST1H2AA histone cluster 1 H2A family member a bA317E16.2, H2AFR 6p22.2
HIST1H2AB histone cluster 1 H2A family member b H2AFM H2A/m 6p22.2
HIST1H2AC histone cluster 1 H2A family member c H2AFL 6p22.2
HIST1H2AD histone cluster 1 H2A family member d H2AFG H2A/g, H2A.3 6p22.2
HIST1H2AE histone cluster 1 H2A family member e H2AFA H2A/a, H2A.1 6p22.2
HIST1H2AG histone cluster 1 H2A family member g H2AFP pH2A/f, H2A/p, H2A.1b 6p22.1
HIST1H2AH histone cluster 1 H2A family member h H2AFALii, dJ86C11.1, H2A/S 6p22.1
HIST1H2AI histone cluster 1 H2A family member i H2AFC H2A/c 6p22.1
HIST1H2AJ histone cluster 1 H2A family member j H2AFE H2A/E 6p22.1
HIST1H2AK histone cluster 1 H2A family member k H2AFD H2A/d 6p22.1
HIST1H2AL histone cluster 1 H2A family member l H2AFI H2A/i, dJ193B12.9 6p22.1
HIST1H2AM histone cluster 1 H2A family member m H2AFN H2A/n, H2A.1 6p22.1
HIST1H2APS1 histone cluster 1 H2A pseudogene 1 bA317E16.5, H2AFSP 6p22.2
HIST1H2APS2 histone cluster 1 H2A pseudogene 2 H2AFTP dJ139G21.2, H2A/T 6p22.2
HIST1H2APS3 histone cluster 1 H2A pseudogene 3 dJ34B20.8, H2AFUP 6p22.2
HIST1H2APS4 histone cluster 1 H2A pseudogene 4 H2AFK, H2AFKP pH2A/k, dJ34B20.2 6p22.2
HIST1H2APS5 histone cluster 1 H2A pseudogene 5 H2AFFP pH2A/f 6p22.2
HIST1H2BA histone cluster 1 H2B family member a bA317E16.3, STBP, TSH2B, H2BFU 6p22.2
HIST1H2BB histone cluster 1 H2B family member b H2BFF H2B/f 6p22.2
HIST1H2BC histone cluster 1 H2B family member c H2BFL H2B/l, H2B.1 6p22.2
HIST1H2BD histone cluster 1 H2B family member d H2BFB H2B/b 6p22.2
HIST1H2BE histone cluster 1 H2B family member e H2BFH H2B/h, H2B.h 6p22.2
HIST1H2BF histone cluster 1 H2B family member f H2BFG H2B/g 6p22.2
HIST1H2BG histone cluster 1 H2B family member g H2BFA H2B/a, H2B.1A 6p22.2
HIST1H2BH histone cluster 1 H2B family member h H2BFJ H2B/j 6p22.2
HIST1H2BI histone cluster 1 H2B family member i H2BFK H2B/k 6p22.2
HIST1H2BJ histone cluster 1 H2B family member j H2BFR H2B/r 6p22.1
HIST1H2BK histone cluster 1 H2B family member k H2BFT H2BFAiii 6p22.1
HIST1H2BL histone cluster 1 H2B family member l H2BFC H2B/c, dJ97D16.4 6p22.1
HIST1H2BM histone cluster 1 H2B family member m H2BFE H2B/e, dJ160A22.3 6p22.1
HIST1H2BN histone cluster 1 H2B family member n H2BFD H2B/d 6p22.1
HIST1H2BO histone cluster 1 H2B family member o H2BFN H2B/n, H2B.2 6p22.1
HIST1H2BPS1 histone cluster 1 H2B pseudogene 1 bA317E16.4, H2BFVP 6p22.2
HIST1H2BPS2 histone cluster 1 H2B pseudogene 2 H2BFIP pH2B/i 6p22.1
HIST1H3A histone cluster 1 H3 family member a H3FA H3/A 6p22.2
HIST1H3B histone cluster 1 H3 family member b H3FL H3/l 6p22.2
HIST1H3C histone cluster 1 H3 family member c H3FC H3/c, H3.1 6p22.2
HIST1H3D histone cluster 1 H3 family member d H3FB H3/b 6p22.2
HIST1H3E histone cluster 1 H3 family member e H3FD H3/d, H3.1 6p22.2
HIST1H3F histone cluster 1 H3 family member f H3FI H3/i 6p22.2
HIST1H3G histone cluster 1 H3 family member g H3FH H3/h 6p22.2
HIST1H3H histone cluster 1 H3 family member h H3FK H3/k, H3F1K 6p22.1
HIST1H3I histone cluster 1 H3 family member i H3FF H3/f, H3.f 6p22.1
HIST1H3J histone cluster 1 H3 family member j H3FJ H3/j 6p22.1
HIST1H3PS1 histone cluster 1 H3 pseudogene 1 dJ45P21.6, H3F3AP1, p36 6p22.2
HIST1H4A histone cluster 1 H4 family member a H4FA 6p22.2
HIST1H4B histone cluster 1 H4 family member b H4FI H4/I 6p22.2
HIST1H4C histone cluster 1 H4 family member c H4FG H4/g, dJ221C16.1 6p22.2
HIST1H4D histone cluster 1 H4 family member d H4FB H4/b 6p22.2
HIST1H4E histone cluster 1 H4 family member e H4FJ H4/j 6p22.2
HIST1H4F histone cluster 1 H4 family member f H4FC H4/c, H4 6p22.2
HIST1H4G histone cluster 1 H4 family member g H4FL H4/l 6p22.2
HIST1H4H histone cluster 1 H4 family member h H4FH H4/h 6p22.2
HIST1H4I histone cluster 1 H4 family member i H4FM H4/m 6p22.1
HIST1H4J histone cluster 1 H4 family member j H4FE H4/e, H4F2iv 6p22.1
HIST1H4K histone cluster 1 H4 family member k H4FD H4/d, H4F2iii, dJ160A22.1 6p22.1
HIST1H4L histone cluster 1 H4 family member l H4FK H4.k, H4/k 6p22.1
HIST1H4PS1 histone cluster 1 H4 pseudogene 1 H4FFP pH4/f, dJ97D16.3 6p22.1
HIST2H2AA3 histone cluster 2 H2A family member a3 H2AFO, HIST2H2AA H2A.2, H2A/q 1q21.2
HIST2H2AA4 histone cluster 2 H2A family member a4 H2A/r 1q21.2
HIST2H2AB histone cluster 2 H2A family member b 1q21.2
HIST2H2AC histone cluster 2 H2A family member c H2A, H2AFQ H2A/q 1q21.2
HIST2H2BA histone cluster 2 H2B family member a (pseudogene) 1p11.2
HIST2H2BB histone cluster 2 H2B family member b (pseudogene) 1q21.1
HIST2H2BC histone cluster 2 H2B family member c (pseudogene) H2B/t 1q21.2
HIST2H2BD histone cluster 2 H2B family member d (pseudogene) H2BFO H2B/s, H2B/o 1q21.2
HIST2H2BE histone cluster 2 H2B family member e H2B, H2BFQ H2B/q, H2B.1 1q21.2
HIST2H2BF histone cluster 2 H2B family member f 1q21.2
HIST2H3A histone cluster 2 H3 family member a H3/n, H3/o 1q21.2
HIST2H3C histone cluster 2 H3 family member c H3F2, H3FM MGC9629, H3/m, H3, H3.2, H3/M 1q21.2
HIST2H3D histone cluster 2 H3 family member d 1q21.2
HIST2H3PS2 histone cluster 2 H3 pseudogene 2 p06 1q21.1
HIST2H4A histone cluster 2 H4 family member a H4F2, H4FN, HIST2H4, H4/n 1q21.2
HIST2H4B histone cluster 2 H4 family member b H4/o 1q21.2
HIST3H2A histone cluster 3 H2A MGC3165 1q42.13
HIST3H2BA histone cluster 3 H2B family member a (pseudogene) 1q42.13
HIST3H2BB histone cluster 3 H2B family member b 1q42.13
HIST3H3 histone cluster 3 H3 H3FT H3t, H3/g, H3.4 1q42.13
HIST4H4 histone cluster 4 H4 MGC24116 12p12.3
H1FNT H1 histone family member N, testis specific HANP1, H1T2 12q13.11
H1FOO H1 histone family member O oocyte specific 3q22.1
H1FX H1 histone family member X MGC15959, MGC8350, H1X 3q21.3
H1F0 H1 histone family member 0 H1FV H10 22q13.1
H2AFB1 H2A histone family member B1 Xq28
H2AFB2 H2A histone family member B2 Xq28
H2AFB3 H2A histone family member B3 H2AFB Xq28
H2AFJ H2A histone family member J FLJ10903, MGC921 12p12.3
H2AFV H2A histone family member V H2AV MGC10170, MGC10831, MGC1947 7p13
H2AFVP1 H2A histone family member V pseudogene 1 H2AFVP HsT19970 15q26.1
H2AFX H2A histone family member X H2AX 11q23.3
H2AFY H2A histone family member Y macroH2A1.2 5q31.1
H2AFY2 H2A histone family member Y2 macroH2A2 10q22.1
H2AFZ H2A histone family member Z H2AZ H2A.Z 4q23
H2AFZP1 H2A histone family member Z pseudogene 1 H2AFZP 21q22.3
H2AFZP2 H2A histone family member Z pseudogene 2 8q13.3
H2AFZP3 H2A histone family member Z pseudogene 3 13q32.3
H2AFZP4 H2A histone family member Z pseudogene 4 11q13.3
H2AFZP5 H2A histone family member Z pseudogene 5 10q22.3
H2AFZP6 H2A histone family member Z pseudogene 6 22q12.2
H2BFM H2B histone family member M Xq22.2
H2BFS H2B histone family member S 21q22.3
H2BFWT H2B histone family member W, testis specific Xq22.2
H2BFXP H2B histone family member X, pseudogene Xq22.2
H3F3A H3 histone family member 3A H3F3 H3.3A 1q42.12
H3F3AP1 H3 histone family member 3A pseudogene 1 HsT18159, p48 15q15.1
H3F3AP2 H3 histone family member 3A pseudogene 2 H3F3CP 14q11.2
H3F3B H3 histone family member 3B H3.3B 17q25.1
H3F3C H3 histone family member 3C H3.5 12p11.21

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