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Gene Family: Tropomyosins (TPM)

Tropomyosins: Tropomyosins are a large family of integral components of actin filaments that play a critical role in regulating the function of actin filaments in both muscle and nonmuscle cells. These proteins consist of rod-shaped coiled-coil hetero- or homo-dimers that lie along the α-helical groove of most actin filaments. Interaction occurs along the length of the actin filament, with dimers aligning in a head-to-tail fashion. [Source: Wikipedia]

Genes contained within the family: 4

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
TPM1 tropomyosin 1 C15orf13, CMH3 15q22.2
TPM2 tropomyosin 2 AMCD1 DA1, NEM4 9p13.3
TPM3 tropomyosin 3 NEM1 TRK 1q21.3
TPM4 tropomyosin 4 19p13.12-p13.11

Publications

25369766