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Gene Family: Tetraspanins (TSPAN)

Also known as : "Tetraspans", "Transmembrane 4 superfamily", "TM4SF"

Tetraspanins: Tetraspanins, also called tetraspans or the transmembrane 4 superfamily (TM4SF), have four transmembrane domains, intracellular N- and C-termini and two extracellular domains, one short (called the small extracellular domain or loop, SED/SEL or EC1) and one longer, typically 100 amino acid residues (the large extracellular domain/loop, LED/LEL or EC2). [Source: Wikipedia]

Genes contained within the family: 33

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
TSPAN1 tetraspanin 1 TSPAN-1, NET-1 1p34.1
TSPAN2 tetraspanin 2 TSPAN-2, TSN2, FLJ12082 1p13.2
TSPAN3 tetraspanin 3 TM4SF8 TM4-A, TSPAN-3 15q24.3
TSPAN4 tetraspanin 4 TM4SF7 NAG-2, TSPAN-4, TETRASPAN 11p15.5
TSPAN5 tetraspanin 5 TM4SF9 Tspan-5, NET-4 4q23
TSPAN6 tetraspanin 6 TM4SF6 T245, TSPAN-6 Xq22.1
TSPAN7 tetraspanin 7 MXS1, TM4SF2, MRX58 DXS1692E, TALLA-1, A15, CD231 Xp11.4
TSPAN8 tetraspanin 8 TM4SF3 CO-029 12q21.1
TSPAN9 tetraspanin 9 NET-5 12p13.33-p13.32
TSPAN10 tetraspanin 10 OCSP 17q25.3
TSPAN11 tetraspanin 11 12p11.21
TSPAN12 tetraspanin 12 TM4SF12 NET-2 7q31.31
TSPAN13 tetraspanin 13 TM4SF13 NET-6 7p21.1
TSPAN14 tetraspanin 14 TM4SF14 DC-TM4F2, MGC11352 10q23.1
TSPAN15 tetraspanin 15 TM4SF15 NET-7 10q22.1
TSPAN16 tetraspanin 16 TM4SF16 TM4-B, TM-8 19p13.2
TSPAN17 tetraspanin 17 FBXO23, TM4SF17 FBX23 5q35.2
TSPAN18 tetraspanin 18 TSPAN 11p11.2
TSPAN19 tetraspanin 19 12q21.31
UPK1B uroplakin 1B UPK1 TSPAN20 3q13.32
UPK1A uroplakin 1A TSPAN21 19q13.12
PRPH2 peripherin 2 RP7, RDS CACD2, TSPAN22, rd2 6p21.1
ROM1 retinal outer segment membrane protein 1 TSPAN23, ROM 11q13
CD151 CD151 molecule (Raph blood group) PETA-3, RAPH, SFA-1, TSPAN24 11p15.5
CD53 CD53 molecule MOX44 TSPAN25 1p13.3
CD37 CD37 molecule TSPAN26 19q13.33
CD82 CD82 molecule ST6, KAI1 IA4, TSPAN27, R2 11p11.2
CD81 CD81 molecule TAPA1 TAPA-1, TSPAN28 11p15.5
CD9 CD9 molecule MIC3 TSPAN29, P24, MRP-1, BA2 12p13.31
CD63 CD63 molecule MLA1 TSPAN30, ME491 12q13.2
TSPAN31 tetraspanin 31 SAS 12q14.1
TSPAN32 tetraspanin 32 TSSC6, PHEMX 11p15.5
TSPAN33 tetraspanin 33 MGC50844, Penumbra 7q32.1