Skip to Navigation

Gene Family: Suppressors of cytokine signaling (SOCS)

SOCS family: SOCS (suppressor of cytokine signaling proteins) refers to a family of genes involved in inhibiting the JAK-STAT signaling pathway. [Source: Wikipedia]

Genes contained within the family: 8

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
CISH cytokine inducible SH2 containing protein CIS, G18, CIS-1, SOCS 3p21.2
SOCS1 suppressor of cytokine signaling 1 SOCS-1, SSI-1, JAB, TIP3, Cish1 16p13.13
SOCS2 suppressor of cytokine signaling 2 STATI2, SSI2, SOCS-2, SSI-2, CIS2, Cish2 12q
SOCS3 suppressor of cytokine signaling 3 SSI-3, CIS3, SOCS-3, Cish3 17q25.3
SOCS4 suppressor of cytokine signaling 4 SOCS7 14q22.3
SOCS5 suppressor of cytokine signaling 5 KIAA0671, SOCS-5, CIS6, CISH6, Cish5 2p21
SOCS6 suppressor of cytokine signaling 6 SOCS4 CIS4, SSI4, HSPC060, STATI4, STAI4, Cish4 18q22.2
SOCS7 suppressor of cytokine signaling 7 NAP4, NCKAP4 17q12