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Gene Family: Sialic acid binding Ig like lectins (SIGLECs)

Also known as : "Sialic acid-binding immunoglobulin-type lectins", "Sialic acid binding Ig-like lectins", "Sialic acid binding immunoglobulin superfamily lectins"

Siglecs: Siglecs (Sialic acid-binding immunoglobulin-type lectins) are cell surface proteins that bind sialic acid. They are found primarily on the surface of immune cells and are a subset of the I-type lectins. There are 14 different mammalian Siglecs, providing an array of different functions based on cell surface receptor-ligand interactions. [Source: Wikipedia]

Genes contained within the family: 28

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
SIGLEC1 sialic acid binding Ig like lectin 1 SN SIGLEC-1, CD169, FLJ00051, FLJ00055, FLJ00073, FLJ32150, dJ1009E24.1, sialoadhesin 20p13
CD22 CD22 molecule SIGLEC-2, SIGLEC2 19q13.12
CD33 CD33 molecule FLJ00391, SIGLEC3, p67, SIGLEC-3 19q13.41
MAG myelin associated glycoprotein GMA SIGLEC4A, SIGLEC-4A, S-MAG 19q13.1
SIGLEC5 sialic acid binding Ig like lectin 5 CD33L2 OB-BP2, SIGLEC-5, CD170 19q13.41
SIGLEC6 sialic acid binding Ig like lectin 6 CD33L, CD33L1 OB-BP1, SIGLEC-6, CD327 19q13.41
SIGLEC7 sialic acid binding Ig like lectin 7 SIGLEC19P, SIGLECP2 SIGLEC-7, p75/AIRM1, QA79, CD328 19q13.41
SIGLEC8 sialic acid binding Ig like lectin 8 SIGLEC-8, SAF2, SIGLEC8L, MGC59785 19q13.33-q13.41
SIGLEC9 sialic acid binding Ig like lectin 9 CD329 19q13.3-q13.4
SIGLEC10 sialic acid binding Ig like lectin 10 SIGLEC-10, SLG2, PRO940, MGC126774 19q13.41
SIGLEC11 sialic acid binding Ig like lectin 11 19q13.33
SIGLEC12 sialic acid binding Ig like lectin 12 (gene/pseudogene) SIGLECL1 SLG, S2V, Siglec-XII, Siglec-12, Siglec-L1 19q13.41
SIGLEC14 sialic acid binding Ig like lectin 14 19q13.41
SIGLEC15 sialic acid binding Ig like lectin 15 CD33L3 HsT1361 18q21.1
SIGLEC16 sialic acid binding Ig like lectin 16 (gene/pseudogene) SIGLECP16 Siglec-P16 19q13.33
SIGLEC17P sialic acid binding Ig like lectin 17, pseudogene SIGLECP3 19q13.41
SIGLEC18P sialic acid binding Ig like lectin 18, pseudogene SIGLECP1 19q13.41
SIGLEC20P sialic acid binding Ig like lectin 20, pseudogene SIGLECP4 19q13.41
SIGLEC21P sialic acid binding Ig like lectin 21, pseudogene SIGLECP5 19q13.41
SIGLEC22P sialic acid binding Ig like lectin 22, pseudogene SIGLECP6 19q13.41
SIGLEC24P sialic acid binding Ig like lectin 24, pseudogene SIGLECP8 19q13.41
SIGLEC25P sialic acid binding Ig like lectin 25, pseudogene SIGLECP9 19q13.41
SIGLEC26P sialic acid binding Ig like lectin 26, pseudogene SIGLECP10 19q13.41
SIGLEC27P sialic acid binding Ig like lectin 27, pseudogene SIGLECP11 19q13.41
SIGLEC28P sialic acid binding Ig like lectin 28, pseudogene SIGLECP12 19q13.41
SIGLEC29P sialic acid binding Ig like lectin 29, pseudogene SIGLECP13 19q13.41
SIGLEC30P sialic acid binding Ig like lectin 30, pseudogene SIGLECP14 1q24.2
SIGLEC31P sialic acid binding Ig like lectin 31, pseudogene SIGLECP15 19q13.43

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