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Gene Family: Short chain dehydrogenase/reductase superfamily (SDR)

Short-chain dehydrogenases: The short-chain dehydrogenases/reductases family (SDR) is a very large family of enzymes, most of which are known to be NAD- or NADP-dependent oxidoreductases. [Source: Wikipedia]

Genes contained within the family: 76

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
GALE UDP-galactose-4-epimerase SDR1E1 1p36.11
TGDS TDP-glucose 4,6-dehydratase TDPGD, SDR2E1 13q32.1
GMDS GDP-mannose 4,6-dehydratase GMD, SDR3E1 6p25.3
TSTA3 tissue specific transplantation antigen P35B FX, SDR4E1, P35B 8q24.3
HSD17B10 hydroxysteroid 17-beta dehydrogenase 10 HADH2, MRXS10 SDR5C1, ABAD, MRPP2, 17b-HSD10, ERAB, CAMR, MHBD Xp11.22
UXS1 UDP-glucuronate decarboxylase 1 UGD, SDR6E1, FLJ23591 2q12.2
RDH11 retinol dehydrogenase 11 MDT1, ARSDR1, SDR7C1 14q24.1
RDH12 retinol dehydrogenase 12 FLJ30273, SDR7C2, RP53, LCA13 14q24.1
RDH13 retinol dehydrogenase 13 SDR7C3 19q13.42
RDH14 retinol dehydrogenase 14 PAN2, SDR7C4 2p24.2
DHRS13 dehydrogenase/reductase 13 SDR7C5, MGC23280 17q11.2
HSD17B4 hydroxysteroid 17-beta dehydrogenase 4 DBP, MFE-2, SDR8C1 5q23.1
BDH1 3-hydroxybutyrate dehydrogenase 1 BDH SDR9C1 3q29
HSD17B2 hydroxysteroid 17-beta dehydrogenase 2 HSD17, SDR9C2 16q23.3
HSD11B2 hydroxysteroid 11-beta dehydrogenase 2 SDR9C3 16q22.1
DHRS9 dehydrogenase/reductase 9 RETSDR8, SDR9C4, RDH15, 3alpha-HSD, RDHL 2q31.1
RDH5 retinol dehydrogenase 5 RDH1 HSD17B9, SDR9C5 12q13.2
HSD17B6 hydroxysteroid 17-beta dehydrogenase 6 RODH, SDR9C6, HSE 12q13.3
SDR9C7 short chain dehydrogenase/reductase family 9C member 7 SDR-O, RDHS 12q13.3
RDH16 retinol dehydrogenase 16 SDR9C8, RODH-4 12q13.3
FAR1 fatty acyl-CoA reductase 1 MLSTD2 SDR10E1, FLJ22728 11p15.3
FAR2 fatty acyl-CoA reductase 2 MLSTD1 SDR10E2, FLJ10462 12p11.22
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 HSDB3, HSD3B SDR11E1 1p12
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 SDR11E2 1p12
HSD3B7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 C(27)-3BETA-HSD, SDR11E3 16p11.2
HSD17B12 hydroxysteroid 17-beta dehydrogenase 12 KAR, SDR12C1 11p11.2
HSD17B3 hydroxysteroid 17-beta dehydrogenase 3 SDR12C2 9q22.32
HSDL1 hydroxysteroid dehydrogenase like 1 SDR12C3 16q24.1
HSDL2 hydroxysteroid dehydrogenase like 2 C9orf99 SDR13C1 9q32
TDH L-threonine dehydrogenase (pseudogene) SDR14E1P, FLJ25033 8p23.1
BDH2 3-hydroxybutyrate dehydrogenase 2 DHRS6 UCPA-OR, FLJ13261, UNQ6308, PRO20933, SDR15C1 4q24
DHRS3 dehydrogenase/reductase 3 SDR16C1, Rsdr1, SDR1, retSDR1, RDH17 1p36.21
HSD17B11 hydroxysteroid 17-beta dehydrogenase 11 DHRS8 17-BETA-HSDXI, RetSDR2, SDR16C2, PAN1B, 17-BETA-HSD11 4q22.1
HSD17B13 hydroxysteroid 17-beta dehydrogenase 13 SCDR9, SDR16C3 4q22.1
RDH10 retinol dehydrogenase 10 SDR16C4 8q21.11
SDR16C5 short chain dehydrogenase/reductase family 16C member 5 RDHE2, RDH-E2, EPHD-2 8q12.1
SDR16C6P short chain dehydrogenase/reductase family 16C member 6, pseudogene SDR16C6 8q12.1
DECR2 2,4-dienoyl-CoA reductase 2 PDCR, SDR17C1 16p13.3
DECR1 2,4-dienoyl-CoA reductase 1 DECR SDR18C1 8q21.3
DHRS1 dehydrogenase/reductase 1 SDR19C1, MGC20204, FLJ25430 14q12
DCXR dicarbonyl and L-xylulose reductase SDR20C1, DCR, KIDCR 17q25.3
CBR1 carbonyl reductase 1 CBR SDR21C1 21q22.12
CBR3 carbonyl reductase 3 SDR21C2 21q22.12
NDUFA9 NADH:ubiquinone oxidoreductase subunit A9 NDUFS2L SDR22E1, CI-39k 12p13.3
MAT2B methionine adenosyltransferase 2B MATIIbeta, SDR23E1 5q34
DHRS11 dehydrogenase/reductase 11 SDR24C1, MGC4172 17q12
DHRS2 dehydrogenase/reductase 2 HEP27, SDR25C1 14q11.2
DHRS4 dehydrogenase/reductase 4 FLJ11008, humNRDR, SDR25C2, SDR-SRL, SCAD-SRL 14q11.2
DHRS4L2 dehydrogenase/reductase 4 like 2 SDR25C3 14q11.2
DHRS4L1 dehydrogenase/reductase 4 like 1 SDR25C4 14q11.2
HSD11B1 hydroxysteroid 11-beta dehydrogenase 1 HSD11B, HSD11 SDR26C1 1q32.2
HSD11B1L hydroxysteroid 11-beta dehydrogenase 1 like SDR26C2, SCDR10 19p13.3
FASN fatty acid synthase FAS, SDR27X1 17q25.3
HSD17B1 hydroxysteroid 17-beta dehydrogenase 1 EDHB17, EDH17B2 SDR28C1, HSD17, MGC138140 17q21.2
RDH8 retinol dehydrogenase 8 SDR28C2, PRRDH 19p13.2
PECR peroxisomal trans-2-enoyl-CoA reductase HSA250303, SDR29C1, TERP 2q35
HSD17B8 hydroxysteroid 17-beta dehydrogenase 8 FABGL KE6, SDR30C1, D6S2245E, RING2, H2-KE6, HKE6 6p21.32
NSDHL NAD(P) dependent steroid dehydrogenase-like SDR31E1, XAP104, H105e3 Xq28
DHRS7B dehydrogenase/reductase 7B CGI-93, SDR32C1, DKFZp566O084, MGC8916 17p11.2
DHRS7C dehydrogenase/reductase 7C SDR32C2 17p13.1
QDPR quinoid dihydropteridine reductase PKU2, SDR33C1, DHPR 4p15.32
DHRS7 dehydrogenase/reductase 7 retDSR4, SDR34C1 14q23.1
KDSR 3-ketodihydrosphingosine reductase FVT1 SDR35C1, DHSR 18q21.33
HPGD 15-hydroxyprostaglandin dehydrogenase SDR36C1 4q34.1
HSD17B7 hydroxysteroid 17-beta dehydrogenase 7 PRAP, SDR37C1 1q23.3
SPR sepiapterin reductase SDR38C1 2p13.2
SDR39U1 short chain dehydrogenase/reductase family 39U member 1 C14orf124 HCDI 14q12
DHRS12 dehydrogenase/reductase 12 FLJ13639, SDR40C1 13q14.3
WWOX WW domain containing oxidoreductase SDR41C1, FOR, WOX1 16q23.1-q23.2
SDR42E1 short chain dehydrogenase/reductase family 42E, member 1 HSPC105 16q23.3
SDR42E2 short chain dehydrogenase/reductase family 42E, member 2 16p12.1
BLVRB biliverdin reductase B FLR SDR43U1 19q13.2
HTATIP2 HIV-1 Tat interactive protein 2 CC3, SDR44U1, FLJ26963, TIP30 11p15.1
CBR4 carbonyl reductase 4 FLJ14431, SDR45C1 4q32.3
HSD17B14 hydroxysteroid 17-beta dehydrogenase 14 DHRS10 SDR47C1, retSDR3 19q13.33
NMRAL1 NmrA like redox sensor 1 HSCARG, SDR48A1, FLJ25918 16p13.3

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