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Gene Family: Short chain dehydrogenase/reductase superfamily (SDR)

Short-chain dehydrogenases: The short-chain dehydrogenases/reductases family (SDR) is a very large family of enzymes, most of which are known to be NAD- or NADP-dependent oxidoreductases. [Source: Wikipedia]

Genes contained within the family: 76

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
GALE UDP-galactose-4-epimerase SDR1E1 1p36.11
TGDS TDP-glucose 4,6-dehydratase TDPGD, SDR2E1 13q32.1
GMDS GDP-mannose 4,6-dehydratase GMD, SDR3E1 6p25.3
TSTA3 tissue specific transplantation antigen P35B FX, SDR4E1, P35B 8q24.3
HSD17B10 hydroxysteroid 17-beta dehydrogenase 10 HADH2, MRXS10 SDR5C1, ABAD, MRPP2, 17b-HSD10, ERAB, CAMR, MHBD Xp11.22
UXS1 UDP-glucuronate decarboxylase 1 UGD, SDR6E1, FLJ23591 2q12.2
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) MDT1, ARSDR1, SDR7C1 14q24.1
RDH12 retinol dehydrogenase 12 (all-trans/9-cis/11-cis) FLJ30273, SDR7C2, RP53, LCA13 14q24.1
RDH13 retinol dehydrogenase 13 SDR7C3 19q13.42
RDH14 retinol dehydrogenase 14 (all-trans/9-cis/11-cis) PAN2, SDR7C4 2p24.2
DHRS13 dehydrogenase/reductase 13 SDR7C5, MGC23280 17q11.2
HSD17B4 hydroxysteroid 17-beta dehydrogenase 4 DBP, MFE-2, SDR8C1 5q23.1
BDH1 3-hydroxybutyrate dehydrogenase 1 BDH SDR9C1 3q29
HSD17B2 hydroxysteroid 17-beta dehydrogenase 2 HSD17, SDR9C2 16q23.3
HSD11B2 hydroxysteroid 11-beta dehydrogenase 2 SDR9C3 16q22.1
DHRS9 dehydrogenase/reductase 9 RETSDR8, SDR9C4, RDH15, 3alpha-HSD, RDHL 2q31.1
RDH5 retinol dehydrogenase 5 RDH1 HSD17B9, SDR9C5 12q13.2
HSD17B6 hydroxysteroid 17-beta dehydrogenase 6 RODH, SDR9C6, HSE 12q13.3
SDR9C7 short chain dehydrogenase/reductase family 9C member 7 SDR-O, RDHS 12q13.3
RDH16 retinol dehydrogenase 16 (all-trans) SDR9C8, RODH-4 12q13.3
FAR1 fatty acyl-CoA reductase 1 MLSTD2 SDR10E1, FLJ22728 11p15.3
FAR2 fatty acyl-CoA reductase 2 MLSTD1 SDR10E2, FLJ10462 12p11.22
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 HSDB3, HSD3B SDR11E1 1p12
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 SDR11E2 1p12
HSD3B7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 C(27)-3BETA-HSD, SDR11E3 16p11.2
HSD17B12 hydroxysteroid 17-beta dehydrogenase 12 KAR, SDR12C1 11p11.2
HSD17B3 hydroxysteroid 17-beta dehydrogenase 3 SDR12C2 9q22.32
HSDL1 hydroxysteroid dehydrogenase like 1 SDR12C3 16q24.1
HSDL2 hydroxysteroid dehydrogenase like 2 C9orf99 SDR13C1 9q32
TDH L-threonine dehydrogenase (pseudogene) SDR14E1P, FLJ25033 8p23.1
BDH2 3-hydroxybutyrate dehydrogenase 2 DHRS6 UCPA-OR, FLJ13261, UNQ6308, PRO20933, SDR15C1 4q24
DHRS3 dehydrogenase/reductase 3 SDR16C1, Rsdr1, SDR1, retSDR1, RDH17 1p36.21
HSD17B11 hydroxysteroid 17-beta dehydrogenase 11 DHRS8 17-BETA-HSDXI, RetSDR2, SDR16C2, PAN1B, 17-BETA-HSD11 4q22.1
HSD17B13 hydroxysteroid 17-beta dehydrogenase 13 SCDR9, SDR16C3 4q22.1
RDH10 retinol dehydrogenase 10 SDR16C4 8q21.11
SDR16C5 short chain dehydrogenase/reductase family 16C member 5 RDHE2, RDH-E2, EPHD-2 8q12.1
SDR16C6P short chain dehydrogenase/reductase family 16C member 6, pseudogene SDR16C6 8q12.1
DECR2 2,4-dienoyl-CoA reductase 2 PDCR, SDR17C1 16p13.3
DECR1 2,4-dienoyl-CoA reductase 1 DECR SDR18C1 8q21.3
DHRS1 dehydrogenase/reductase 1 SDR19C1, MGC20204, FLJ25430 14q12
DCXR dicarbonyl and L-xylulose reductase SDR20C1, DCR, KIDCR 17q25.3
CBR1 carbonyl reductase 1 CBR SDR21C1 21q22.12
CBR3 carbonyl reductase 3 SDR21C2 21q22.12
NDUFA9 NADH:ubiquinone oxidoreductase subunit A9 NDUFS2L SDR22E1, CI-39k 12p13.3
MAT2B methionine adenosyltransferase 2B MATIIbeta, SDR23E1 5q34
DHRS11 dehydrogenase/reductase 11 SDR24C1, MGC4172 17q12
DHRS2 dehydrogenase/reductase 2 HEP27, SDR25C1 14q11.2
DHRS4 dehydrogenase/reductase 4 FLJ11008, humNRDR, SDR25C2, SDR-SRL, SCAD-SRL 14q11.2
DHRS4L2 dehydrogenase/reductase 4 like 2 SDR25C3 14q11.2
DHRS4L1 dehydrogenase/reductase 4 like 1 SDR25C4 14q11.2
HSD11B1 hydroxysteroid 11-beta dehydrogenase 1 HSD11B, HSD11 SDR26C1 1q32.2
HSD11B1L hydroxysteroid 11-beta dehydrogenase 1 like SDR26C2, SCDR10 19p13.3
FASN fatty acid synthase FAS, SDR27X1 17q25.3
HSD17B1 hydroxysteroid 17-beta dehydrogenase 1 EDHB17, EDH17B2 SDR28C1, HSD17, MGC138140 17q21.2
RDH8 retinol dehydrogenase 8 (all-trans) SDR28C2, PRRDH 19p13.2
PECR peroxisomal trans-2-enoyl-CoA reductase HSA250303, SDR29C1, TERP 2q35
HSD17B8 hydroxysteroid 17-beta dehydrogenase 8 FABGL KE6, SDR30C1, D6S2245E, RING2, H2-KE6, HKE6 6p21.32
NSDHL NAD(P) dependent steroid dehydrogenase-like SDR31E1, XAP104, H105e3 Xq28
DHRS7B dehydrogenase/reductase 7B CGI-93, SDR32C1, DKFZp566O084, MGC8916 17p11.2
DHRS7C dehydrogenase/reductase 7C SDR32C2 17p13.1
QDPR quinoid dihydropteridine reductase PKU2, SDR33C1, DHPR 4p15.32
DHRS7 dehydrogenase/reductase 7 retDSR4, SDR34C1 14q23.1
KDSR 3-ketodihydrosphingosine reductase FVT1 SDR35C1, DHSR 18q21.33
HPGD 15-hydroxyprostaglandin dehydrogenase SDR36C1 4q34.1
HSD17B7 hydroxysteroid 17-beta dehydrogenase 7 PRAP, SDR37C1 1q23.3
SPR sepiapterin reductase SDR38C1 2p13.2
SDR39U1 short chain dehydrogenase/reductase family 39U member 1 C14orf124 HCDI 14q12
DHRS12 dehydrogenase/reductase 12 FLJ13639, SDR40C1 13q14.3
WWOX WW domain containing oxidoreductase SDR41C1, FOR, WOX1 16q23.1-q23.2
SDR42E1 short chain dehydrogenase/reductase family 42E, member 1 HSPC105 16q23.3
SDR42E2 short chain dehydrogenase/reductase family 42E, member 2 16p12.1
BLVRB biliverdin reductase B FLR SDR43U1 19q13.2
HTATIP2 HIV-1 Tat interactive protein 2 CC3, SDR44U1, FLJ26963, TIP30 11p15.1
CBR4 carbonyl reductase 4 FLJ14431, SDR45C1 4q32.3
HSD17B14 hydroxysteroid 17-beta dehydrogenase 14 DHRS10 SDR47C1, retSDR3 19q13.33
NMRAL1 NmrA like redox sensor 1 HSCARG, SDR48A1, FLJ25918 16p13.3

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