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Gene Family: Serine proteases (PRSS)

Also known as : "Serine peptidases", "Serine endopeptidases", "Proteases, serine"

Serine peptidases: Serine proteases (or serine endopeptidases) are enzymes that cleave peptide bonds in proteins, in which serine serves as the nucleophilic amino acid at the (enzyme's) active site. [Source: Wikipedia]

Genes contained within the family: 63

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
PRSS1 serine protease 1 TRY1 7q34
PRSS2 serine protease 2 TRY2 7q34
PRSS3 serine protease 3 PRSS4 TRY3, TRY4 9p13.3
MASP1 mannan binding lectin serine peptidase 1 PRSS5, CRARF MASP 3q27.3
KLK7 kallikrein related peptidase 7 PRSS6 SCCE 19q13.33
PRSS8 serine protease 8 16p11.2
KLK6 kallikrein related peptidase 6 PRSS18, PRSS9 Bssp, Klk7, neurosin 19q13.3
HTRA1 HtrA serine peptidase 1 PRSS11 HtrA, IGFBP5-protease, ARMD7 10q26.13
PRSS12 serine protease 12 BSSP-3, MRT1 4q26
LONP1 lon peptidase 1, mitochondrial PRSS15 LonHS, hLON, PIM1 19p13.2
PRSS16 serine protease 16 TSSP 6p22.1
KLK4 kallikrein related peptidase 4 PRSS17 EMSP, EMSP1, PSTS, KLK-L1 19q13.41
KLK8 kallikrein related peptidase 8 PRSS19 HNP, TADG14, neuropsin, ovasin 19q13
KLK11 kallikrein related peptidase 11 PRSS20 TLSP 19q13.41
PRSS21 serine protease 21 ESP-1, TEST1 16p13.3
PRSS22 serine protease 22 hBSSP-4, BSSP-4, SP001LA 16p13.3
PRSS23 serine protease 23 SPUVE, SIG13 11q14.2
STEAP1 STEAP family member 1 STEAP PRSS24 7q21.13
HTRA2 HtrA serine peptidase 2 PRSS25 OMI, PARK13 2p13.1
ENDOU endonuclease, poly(U) specific P11, PRSS26, PP11 12q13.11
PRSS27 serine protease 27 MPN, CAPH2 16p13.3
PRSS29P serine protease 29, pseudogene Isp2 16p13.3
PRSS30P serine protease 30, pseudogene TMPRSS8, TMPRSS8P Disp, MGC5228 16p13.3
TPSG1 tryptase gamma 1 PRSS31, TMT 16p13.3
PRSS33 serine protease 33 EOS 16p13.3
PRSS35 serine protease 35 C6orf158 MGC46520, dJ223E3.1 6q14.2
PRSS36 serine protease 36 FLJ90661 16p11.2
PRSS37 serine protease 37 7q34
PRSS38 serine protease 38 MPN2 1q42.13
PRSS41 serine protease 41 TESSP1 16p13.3
PRSS42 serine protease 42 TESSP2 3p21.31
PRSS43 serine protease 43 TESSP3 3p21.31
PRSS44 serine protease 44 TESSP4 3p21.31
PRSS45 serine protease 45 TESSP5 3p21.31
PRSS46P serine protease 46, pseudogene PRSS46 TESSP6 3p21.31
PRSS47 serine protease 47 9q22.31
PRSS48 serine protease 48 ESSPL 4q31.3
PRSS50 serine protease 50 TSP50, CT20 3p21.31
PRSS53 serine protease 53 POL3S 16p11.2
PRSS54 serine protease 54 FLJ25339, KLKBL4, CT67 16q21
PRSS55 serine protease 55 T-SP1, UNQ9391, CT153 8p23.1
PRSS56 serine protease 56 2q37.1
PRSS57 serine protease 57 PRSSL1 UNQ782 19p13.3
PRSS58 serine protease 58 TRYX3 7q34
HPN hepsin TMPRSS1 19q13.11
TMPRSS2 transmembrane serine protease 2 PRSS10 21q22.3
TMPRSS3 transmembrane serine protease 3 DFNB10, DFNB8 21q22.3
TMPRSS4 transmembrane serine protease 4 TMPRSS3, MT-SP2 11q23.3
TMPRSS5 transmembrane serine protease 5 MGC141886, MGC148044 11q23.2
TMPRSS6 transmembrane serine protease 6 FLJ30744 22q12.3
TMPRSS7 transmembrane serine protease 7 3q13.2
TMPRSS9 transmembrane serine protease 9 19p13.3
CORIN corin, serine peptidase PRSC, ATC2, CRN, Lrp4, TMPRSS10 4p12
TMPRSS11A transmembrane serine protease 11A ECRG1 4q13.2
TMPRSS11B transmembrane serine protease 11B 4q13.2
TMPRSS11CP transmembrane serine protease 11C, pseudogene 4q13.2
TMPRSS11D transmembrane serine protease 11D 4q13.2
TMPRSS11E transmembrane serine protease 11E TMPRSS11E2 DESC1 4q13.2
TMPRSS11F transmembrane serine protease 11F FLJ16046 4q13.2
TMPRSS12 transmembrane serine protease 12 MGC57341, CT151 12q13.12
TMPRSS13 transmembrane serine protease 13 TMPRSS11 MSPL 11q23.3
ST14 suppression of tumorigenicity 14 PRSS14 SNC19, TMPRSS14, MT-SP1, HAI 11q24.3
TMPRSS15 transmembrane serine protease 15 PRSS7 ENTK, MGC133046 21q21.1