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Gene Family: Semaphorins (SEMA)

Semaphorins: Semaphorins are a class of secreted and membrane proteins that act as axonal growth cone guidance molecules. They primarily act as short-range inhibitory signals and signal through multimeric receptor complexes. [Source: Wikipedia]

Genes contained within the family: 20

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
SEMA3A semaphorin 3A SEMAD SEMA1, SemD, coll-1, Hsema-I 7q21.11
SEMA3B semaphorin 3B SEMAA SemA, semaV, LUCA-1, sema5 3p21.31
SEMA3C semaphorin 3C SEMAE SemE 7q21.11
SEMA3D semaphorin 3D coll-2, Sema-Z2 7q21.11
SEMA3E semaphorin 3E SEMAH M-SemaK, KIAA0331, coll-5 7q21.11
SEMA3F semaphorin 3F SEMAK, Sema4 3p21.31
SEMA3G semaphorin 3G FLJ00014, sem2 3p21.1
SEMA4A semaphorin 4A SEMAB SemB, FLJ12287, CORD10 1q22
SEMA4B semaphorin 4B SEMAC SemC, KIAA1745, MGC131831 15q25
SEMA4C semaphorin 4C SEMAI Semacl1, Semaf 2q11.2
SEMA4D semaphorin 4D SEMAJ, C9orf164 CD100, coll-4, FLJ39737 9q22.2
SEMA4F ssemaphorin 4F SEMAM SEMAW 2p13.1
SEMA4G semaphorin 4G FLJ20590, KIAA1619 10q24.31
SEMA5A semaphorin 5A SEMAF semF 5p15.31
SEMA5B semaphorin 5B SEMAG SemG, KIAA1445, FLJ10372 3q21.1
SEMA6A semaphorin 6A SEMAQ KIAA1368, SEMA6A1, SEMA, HT018 5q23.1
SEMA6B semaphorin 6B SEMAN semaZ, SEMA-VIB, SEM-SEMA-Y 19p13.3
SEMA6C semaphorin 6C KIAA1869 1q21.3
SEMA6D semaphorin 6D KIAA1479, FLJ11598 15q21.1
SEMA7A semaphorin 7A (John Milton Hagen blood group) SEMAL H-Sema-L, CD108 15q24.1

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