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Gene Family: Secreted frizzled-related proteins (SFRP)

SFRPs: The Secreted frizzled-related protein (SFRP) family consists of five secreted glycoproteins in humans (SFRP1, SFRP2, SFRP3 [FRZB], SFRP4, SFRP5) that act as extracellular signaling ligands. Each SFRP is around 300 amino acids in length and contains a cysteine-rich domain (CRD) that shares 30-50% sequence homology with the CRD of Frizzled (Fz) receptors. SFRPs are able to bind Wnt proteins and Fz receptors in the extracellular compartment. [Source: Wikipedia]

Genes contained within the family: 5

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
SFRP1 secreted frizzled related protein 1 SARP2, FRP, FRP-1 8p11.21
SFRP2 secreted frizzled related protein 2 SARP1, SDF-5, FRP-2 4q31.3
FRZB frizzled related protein FZRB, hFIZ, FRZB-1, FRZB-PEN, FRITZ, SFRP3, SRFP3, FRP-3, FRE, FRZB1 2q32.1
SFRP4 secreted frizzled related protein 4 frpHE, FRP-4, FRPHE, FRZB-2 7p14.1
SFRP5 secreted frizzled related protein 5 SARP3 10q24.2