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Gene Family: Oxysterol binding proteins (OSBP)

Also known as : "Oxysterol-binding proteins", "Oxysterol-binding protein related-proteins", "ORPs"

Oxysterol-binding protein: Oxysterol-binding proteins, or Oxysterol-binding protein related-proteins, or simply ORPs, are evolutionary related proteins involved in sterol synthesis and/or its regulation. These include mammalian oxysterol-binding protein (OSBP), a protein of about 800 amino-acid residues that binds oxysterols (oxygenated derivatives of cholesterol), cholesterol and phosphatidylinositol 4-phosphate (PI4P); yeast Osh1, a protein of 859 residues that plays a role in ergosterol synthesis; and yeast proteins HES1 and KES1, highly related proteins of 434 residues that seem to play a role in ergosterol synthesis [Source: Wikipedia]

Genes contained within the family: 12

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
OSBP oxysterol binding protein OSBP1 11q12.1
OSBPL1A oxysterol binding protein like 1A OSBPL1B ORP-1, ORP1 18q11.2
OSBPL2 oxysterol binding protein like 2 KIAA0772, ORP-2, DFNA67 20q13.33
OSBPL3 oxysterol binding protein like 3 OSBP3 ORP-3, ORP3, KIAA0704 7p15.3
OSBPL5 oxysterol binding protein like 5 KIAA1534, ORP5 11p15.4
OSBPL6 oxysterol binding protein like 6 ORP6 2q31.2
OSBPL7 oxysterol binding protein like 7 ORP7, MGC71150 17q21
OSBPL8 oxysterol binding protein like 8 OSBP10, ORP8, MST120, MSTP120 12q14
OSBPL9 oxysterol binding protein like 9 1p32.3
OSBPL10 oxysterol binding protein like 10 3p23
OSBPL11 oxysterol binding protein like 11 ORP-11, ORP11, FLJ13012, FLJ13164 3q21.2
OSBP2 oxysterol binding protein 2 OSBPL1 KIAA1664, ORP-4, ORP4 22q12.2

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