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Gene Family: Mitochondrial complex V: ATP synthase subunits (ATP5, MT-ATP)

Also known as : "F-ATPase", "ATP synthase subunits", "F1-ATPase", "FoF1-ATPase", "F-type ATPase", "Complex V"

ATP synthase: ATP synthase ( EC 3.6.3.14 ) is an important enzyme that provides energy for the cell to use through the synthesis of adenosine triphosphate (ATP). ATP is the most commonly used "energy currency" of cells from most organisms. It is formed from adenosine diphosphate (ADP) and inorganic phosphate (P i), and needs energy. The overall reaction sequence is: ADP + P = ATP, where ADP and P i are joined together by ATP synthase Energy is often released in the form of hydrogen ions ( H+ ), moving down an electrochemical gradient, such as from the lumen into the stroma of chloroplasts or from the inter-membrane space into the matrix in mitochondria. [Source: Wikipedia]

Genes contained within the family: 20

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
ATP5F1A ATP synthase F1 subunit alpha ATP5AL2, ATPM, ATP5A1 ATP5A, hATP1, OMR, ORM 18q21.1
ATP5F1B ATP synthase F1 subunit beta ATPSB, ATP5B 12q13.3
ATP5F1C ATP synthase F1 subunit gamma ATP5CL1, ATP5C, ATP5C1 10p14
ATP5F1D ATP synthase F1 subunit delta ATP5D 19p13.3
ATP5F1E ATP synthase F1 subunit epsilon ATP5E 20q13.32
ATP5MC1 ATP synthase membrane subunit c locus 1 ATP5G, ATP5G1 17q21.32
ATP5MC2 ATP synthase membrane subunit c locus 2 ATP5G2 12q13.13
ATP5MC3 ATP synthase membrane subunit c locus 3 ATP5G3 2q31.1
ATP5MD ATP synthase membrane subunit DAPIT USMG5 MGC14697, bA792D24.4, DAPIT 10q24.33
ATP5ME ATP synthase membrane subunit e ATP5I 4p16.3
ATP5MF ATP synthase membrane subunit f ATP5J2 ATP5JL 7q22.1
ATP5MG ATP synthase membrane subunit g ATP5L ATP5JG 11q23.3
ATP5MPL ATP synthase membrane subunit 6.8PL C14orf2 MP68, MLQ, 6.8PL 14q32.33
MT-ATP6 mitochondrially encoded ATP synthase membrane subunit 6 MTATP6, RP ATP6, ATPase-6, Su6m mitochondria
MT-ATP8 mitochondrially encoded ATP synthase membrane subunit 8 MTATP8 ATP8, A6L mitochondria
ATP5PB ATP synthase peripheral stalk-membrane subunit b ATP5F1 1p13.2
ATP5PD ATP synthase peripheral stalk subunit d ATP5H ATPQ, ATP5JD 17q25.1
ATP5PF ATP synthase peripheral stalk subunit F6 ATP5A, ATP5, ATPM, ATP5J CF6 21q21.3
ATP5PO ATP synthase peripheral stalk subunit OSCP ATP5O OSCP, ATPO 21q22.11
ATP5IF1 ATP synthase inhibitory factor subunit 1 ATPIF1 ATPI, IP, ATPIP, MGC1167, MGC8898 1p35.3

Publications

26439008,25851905