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Gene Family: Intraflagellar transport proteins (IFT)

Intraflagellar transport: Intraflagellar transport or IFT is a bidirectional motility along axonemal microtubules that is essential for the formation ( ciliogenesis ) and maintenance of most eukaryotic cilia and flagella. It is thought to be required to build all cilia that assemble within a membrane projection from the cell surface. The process of IFT has been best characterized in the biflagellate alga Chlamydomonas reinhardtii as well as the sensory cilia of the nematode Caenorhabditis elegans. It has been suggested based on localization studies that IFT proteins also function outside of cilia. [Source: Wikipedia]

Genes contained within the family: 24

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
IFT20 intraflagellar transport 20 17q11.2
IFT22 intraflagellar transport 22 RABL5 FLJ14117, FLJ13225, DKFZp761N0823 7q22.1
HSPB11 heat shock protein family B (small) member 11 C1orf41 HSPCO34, IFT25, PP25 1p32.3
IFT27 intraflagellar transport 27 RABL4 RAYL, BBS19 22q12.3
CLUAP1 clusterin associated protein 1 FLJ13297, KIAA0643, FAP22, IFT38, CFAP22 16p13.3
IFT43 intraflagellar transport 43 C14orf179 FLJ32173, MGC16028 14q24.3
IFT46 intraflagellar transport 46 C11orf60 C11orf2, FLJ21827, CFAP32 11q23.3
IFT52 intraflagellar transport 52 C20orf9 CGI-53, NGD5, dJ1028D15.1, NGD2 20q13.12
TRAF3IP1 TRAF3 interacting protein 1 IFT54, MIPT3, MIP-T3, DKFZP434F124 2q37.3
TTC26 tetratricopeptide repeat domain 26 IFT56, FLJ12571, dyf-13, DYF13 7q34
IFT57 intraflagellar transport 57 ESRRBL1 FLJ10147, HIPPI, MHS4R2 3q13.12-q13.13
TTC30A tetratricopeptide repeat domain 30A IFT70A, FLJ13946 2q31.2
TTC30B tetratricopeptide repeat domain 30B IFT70B, fleer, FLJ30990 2q31.2
IFT74 intraflagellar transport 74 CCDC2 CMG1, CMG-1, FLJ22621 9p21.2
IFT80 intraflagellar transport 80 WDR56 KIAA1374 3q25.33
IFT81 intraflagellar transport 81 CDV1 CDV-1R, MGC4027 12q24.11
IFT88 intraflagellar transport 88 TTC10 hTg737, Tg737, D13S1056E, MGC26259 13q12.11
WDR35 WD repeat domain 35 KIAA1336, MGC33196, IFTA1, IFT121 2p24.1
IFT122 intraflagellar transport 122 WDR10 WDR140, WDR10p, SPG 3q21.3-q22.1
TTC21A tetratricopeptide repeat domain 21A IFT139A, STI2 3p22.2
TTC21B tetratricopeptide repeat domain 21B JBTS11, FLJ11457, THM1, IFT139B, NPHP12 2q24.3
IFT140 intraflagellar transport 140 WDTC2 gs114, KIAA0590 16p13.3
WDR19 WD repeat domain 19 Pwdmp, ORF26, KIAA1638, DYF-2, NPHP13, Oseg6, FLJ23127, IFT144 4p14
IFT172 intraflagellar transport 172 SLB, wim, osm-1, NPHP17, BBS20 2p23.3