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Gene Family: C2-set domain containing

Immunoglobulin C2-set domain: C2-set domains, which are Ig-like domains resembling the antibody constant domain. C2-set domains are found primarily in the mammalian T-cell surface antigens CD2 (Cluster of Differentiation 2), CD4 and CD80, as well as in vascular (VCAM) and intercellular (ICAM) cell adhesion molecules. [Source: Wikipedia]

Genes contained within the family: 40

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
AGER advanced glycosylation end-product specific receptor RAGE, SCARJ1 6p21.32
ALCAM activated leukocyte cell adhesion molecule CD166, MEMD 3q13.11
BCAM basal cell adhesion molecule (Lutheran blood group) LU CD239 19q13.32
BTNL2 butyrophilin like 2 HSBLMHC1, BTL-II, BTN7 6p21.32
BTN1A1 butyrophilin subfamily 1 member A1 BTN BT, BTN1 6p22.2
BTN2A1 butyrophilin subfamily 2 member A1 BT2.1, BTF1, BTN2.1 6p22.2
BTN2A2 butyrophilin subfamily 2 member A2 BTF2, BT2.2, BTN2.2 6p22.2
BTN3A1 butyrophilin subfamily 3 member A1 BT3.1, BTF5, CD277, BTN3.1 6p22.2
CADM1 cell adhesion molecule 1 TSLC1, IGSF4 NECL2, ST17, BL2, SYNCAM, IGSF4A, Necl-2, SYNCAM1, RA175 11q23.3
CADM2 cell adhesion molecule 2 IGSF4D NECL3, Necl-3, SynCAM2 3p12.1
CADM3 cell adhesion molecule 3 IGSF4B BIgR, FLJ10698, TSLL1, NECL1, SynCAM3, Necl-1 1q23.2
CADM4 cell adhesion molecule 4 IGSF4C TSLL2, Necl-4, SynCAM4 19q13.31
CD2 CD2 molecule SRBC 1p13.1
CD4 CD4 molecule 12p13.31
CD22 CD22 molecule SIGLEC-2, SIGLEC2 19q13.12
CD80 CD80 molecule CD28LG, CD28LG1 B7.1, B7-1 3q13.33
CD200R1 CD200 receptor 1 MOX2R OX2R, HCRTR2, CD200R 3q13.2
CD200R1L CD200 receptor 1 like CD200RLa, CD200R2 3q13.2
CD274 CD274 molecule PDCD1LG1 B7-H, B7H1, PD-L1, PDL1, B7-H1 9p24.1
CD276 CD276 molecule B7-H3, B7H3, B7RP-2 15q24.1
CRTAM cytotoxic and regulatory T cell molecule CD355 11q24.1
ICOSLG inducible T cell costimulator ligand ICOSL KIAA0653, GL50, B7-H2, B7RP-1, B7H2, B7RP1, ICOS-L, CD275 21q22.3
KIRREL1 kirre like nephrin family adhesion molecule 1 KIRREL NEPH1 1q23.1
KIRREL2 kirre like nephrin family adhesion molecule 2 NLG1, NEPH3, FILTRIN, DKFZp564A1164, MGC15718 19q13.12
KIRREL3 kirre like nephrin family adhesion molecule 3 NEPH2, KIAA1867, KIRRE 11q24.2
MAG myelin associated glycoprotein GMA SIGLEC4A, SIGLEC-4A, S-MAG 19q13.1
MCAM melanoma cell adhesion molecule MUC18, CD146, MelCAM, METCAM, HEMCAM 11q23.3
NPHS1 NPHS1, nephrin CNF, NPHN 19q13.12
PVR poliovirus receptor PVS CD155, HVED, Necl-5, NECL5, Tage4 19q13.31
NECTIN1 nectin cell adhesion molecule 1 ED4, PVRL1, HVEC PRR, PRR1, PVRR1, SK-12, HIgR, CLPED1, CD111, OFC7 11q23.3
NECTIN2 nectin cell adhesion molecule 2 HVEB, PVRL2 PVRR2, PRR2, CD112 19q13.32
NECTIN3 nectin cell adhesion molecule 3 PVRL3 nectin-3, PPR3, PVRR3, DKFZP566B0846, CDw113, CD113 3q13.13
NECTIN4 nectin cell adhesion molecule 4 PVRL4 nectin-4, PRR4, LNIR 1q23.3
SIGLEC1 sialic acid binding Ig like lectin 1 SN SIGLEC-1, CD169, FLJ00051, FLJ00055, FLJ00073, FLJ32150, dJ1009E24.1, sialoadhesin 20p13
SIGLEC10 sialic acid binding Ig like lectin 10 SIGLEC-10, SLG2, PRO940, MGC126774 19q13.41
SIGLEC11 sialic acid binding Ig like lectin 11 19q13.33
SIGLEC12 sialic acid binding Ig like lectin 12 (gene/pseudogene) SIGLECL1 SLG, S2V, Siglec-XII, Siglec-12, Siglec-L1 19q13.41
SIGLEC16 sialic acid binding Ig like lectin 16 (gene/pseudogene) SIGLECP16 Siglec-P16 19q13.33
TMEM25 transmembrane protein 25 FLJ14399 11q23.3
VCAM1 vascular cell adhesion molecule 1 CD106 1p21.2