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Gene Family: Exonucleases

Exonuclease: Enzyme that degrades DNA or RNA by progressively splitting off single nucleotides from one end of the chain. [Source: UniProt. See also GO]

Genes contained within the family: 16

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
AEN apoptosis enhancing nuclease ISG20L1 FLJ12484, FLJ12562 15q26.1
ERI1 exoribonuclease 1 THEX1 3'HEXO 8p23.1
ERI2 ERI1 exoribonuclease family member 2 EXOD1 KIAA1504, MGC16943, ZGRF5 16p12.3
ERI3 ERI1 exoribonuclease family member 3 PRNPIP FLJ22943, PINT1 1p34.1
EXO1 exonuclease 1 HEX1, hExoI 1q43
EXO5 exonuclease 5 C1orf176, DEM1 FLJ21144 1p34.2
ISG20 interferon stimulated exonuclease gene 20 HEM45, CD25 15q26.1
ISG20L2 interferon stimulated exonuclease gene 20 like 2 FLJ12671 1q23.1
MGME1 mitochondrial genome maintenance exonuclease 1 C20orf72 bA504H3.4, DDK1 20p11.23
PAN2 poly(A) specific ribonuclease subunit PAN2 USP52 KIAA0710, hPAN2 12q13.3
REXO1 RNA exonuclease 1 homolog TCEB3BP1 EloA-BP1, KIAA1138 19p13.3
REXO2 RNA exonuclease 2 DKFZP566E144, SFN, CGI-114 11q23.2
REXO4 REX4 homolog, 3'-5' exonuclease XPMC2H hPMC2 9q34.2
TREX1 three prime repair exonuclease 1 AGS1 DRN3 3p21.31
TREX2 three prime repair exonuclease 2 Xq28
WRN Werner syndrome RecQ like helicase RECQL2, RECQ3 8p12