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Gene Family: EMI domain containing

EMI domain: In molecular biology, the EMI domain, first named after its presence in proteins of the EMILIN family, is a small cysteine -rich protein domain of around 75 amino acids. The EMI domain is most often found at the N terminus of metazoan extracellular proteins that are forming or are compatible with multimer formation. It is found in association with other domains, such as C1q, laminin-type EGF-like, collagen-like, FN3, WAP, ZP or FAS1. It has been suggested that the EMI domain could be a protein-protein interaction module, as the EMI domain of EMILIN-1 was found to interact with the C1q domain of EMILIN-2. [Source: Wikipedia]

Genes contained within the family: 7

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
COL26A1 collagen type XXVI alpha 1 chain EMID2 Emu2, EMI6 7q22.1
EMID1 EMI domain containing 1 EMU1, hEmu1, EMI5 22q12.2
EMILIN1 elastin microfibril interfacer 1 DKFZp586M121, gp115 2p23.3
EMILIN2 elastin microfibril interfacer 2 FLJ33200, FOAP-10 18p11.32-p11.31
EMILIN3 elastin microfibril interfacer 3 C20orf130, EMILIN5 dJ620E11.4 20q12
MMRN1 multimerin 1 MMRN ECM, EMILIN4, GPIa* 4q22.1
MMRN2 multimerin 2 EMILIN3 EndoGlyx-1, FLJ13465 10q23.2