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Gene Family: DNA polymerases (POL)

Also known as : "DNA-directed DNA polymerases", "Polymerases, DNA directed"

DNA-directed DNA polymerase: Enzyme that catalyzes DNA synthesis by addition of deoxyribonucleotide units to a DNA chain using DNA as a template. They can also possess exonuclease activity and therefore function in DNA repair. [Source: UniProt. See also GO]

Genes contained within the family: 23

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
DNTT DNA nucleotidylexotransferase TDT 10q24.1
POLA1 DNA polymerase alpha 1, catalytic subunit POLA, NSX p180 Xp22.11-p21.3
POLA2 DNA polymerase alpha 2, accessory subunit FLJ21662 11q13.1
POLB DNA polymerase beta 8p11.21
POLD1 DNA polymerase delta 1, catalytic subunit POLD CDC2 19q13.3
POLD2 DNA polymerase delta 2, accessory subunit 7p13
POLD3 DNA polymerase delta 3, accessory subunit P66, KIAA0039, P68, PPP1R128 11q13.4
POLD4 DNA polymerase delta 4, accessory subunit p12, POLDS 11q13.2
POLE DNA polymerase epsilon, catalytic subunit POLE1 12q24.33
POLE2 DNA polymerase epsilon 2, accessory subunit DPE2 14q21.3
POLE3 DNA polymerase epsilon 3, accessory subunit CHRAC17, Ybl1, p17, CHARAC17, CHRAC2 9q32
POLE4 DNA polymerase epsilon 4, accessory subunit p12 2p12
POLG DNA polymerase gamma, catalytic subunit POLG1, POLGA 15q26.1
POLG2 DNA polymerase gamma 2, accessory subunit MTPOLB, HP55 17q23.3
POLI DNA polymerase iota RAD3OB, RAD30B 18q21.2
POLK DNA polymerase kappa DINB1 POLQ, DINP 5q13.3
POLL DNA polymerase lambda 10q24.32
POLM DNA polymerase mu Tdt-N 7p13
POLN DNA polymerase nu 4p16.3
POLQ DNA polymerase theta POLH 3q13.33
REV3L REV3 like, DNA directed polymerase zeta catalytic subunit POLZ, REV3 6q21
MAD2L2 mitotic arrest deficient 2 like 2 POLZ2, REV7, FANCV, MAD2B 1p36.22
REV1 REV1, DNA directed polymerase REV1L 2q11.2