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Gene Family: DENN/MADD domain containing (DENND)

Genes contained within the family: 29

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
AVL9 AVL9 cell migration associated KIAA0241 7p14.3
MADD MAP kinase activating death domain KIAA0358, RAB3GEP, DENN 11p11.2
DENND1A DENN domain containing 1A KIAA1608 FLJ21129, FAM31A 9q33.3
DENND1B DENN domain containing 1B FAM31B, C1orf218 MGC27044, FLJ20054 1q31.3
DENND1C DENN domain containing 1C FAM31C FLJ22757 19p13.3
DENND2A DENN domain containing 2A KIAA1277 FAM31D 7q34
ST5 suppression of tumorigenicity 5 HTS1, DENND2B, p126 11p15.4
DENND2C DENN domain containing 2C FLJ37099, DKFZp686G0351, DKFZp779P1149, dJ1156J9.1, RP5-1156J9.1 1p13.2
DENND2D DENN domain containing 2D FLJ22457, RP5-1180E21.2 1p13.3-p13.2
DENND3 DENN domain containing 3 KIAA0870 8q24.3
DENND4A DENN domain containing 4A MYCPBP IRLB 15q22.31
DENND4B DENN domain containing 4B KIAA0476 1q21.3
DENND4C DENN domain containing 4C C9orf55B, C9orf55 FLJ20686, bA513M16.3, RAB10GEF 9p22.1
DENND5A DENN domain containing 5A RAB6IP1 KIAA1091, FLJ22354, FLJ33829, FLJ43455 11p15.4
DENND5B DENN domain containing 5B MGC24039 12p11.21
DENND6A DENN domain containing 6A FAM116A FLJ34969, AFI1A 3p14.3
DENND6B DENN domain containing 6B FAM116B MGC33692, AFI1B 22q13.33
SBF1 SET binding factor 1 DENND7A, MTMR5 22q13.33
SBF2 SET binding factor 2 CMT4B2 DENND7B, MTMR13, KIAA1766 11p15.4
SMCR8 Smith-Magenis syndrome chromosome region, candidate 8 FLJ34716 17p11.2
FLCN folliculin BHD, MGC17998, MGC23445 17p11.2
C9orf72 chromosome 9 open reading frame 72 MGC23980, DENNL72 9p21.2
FNIP1 folliculin interacting protein 1 KIAA1961 5q31.1
FNIP2 folliculin interacting protein 2 KIAA1450, FNIPL, MAPO1 4q32.1
NPR2 natriuretic peptide receptor 2 ANPRB, NPRB, AMDM GUCY2B, ANPb 9p13.3
NPR3 natriuretic peptide receptor 3 NPRC, ANPRC, C5orf23 GUCY2B, FLJ14054 5p13.3
FAM45A family with sequence similarity 45 member A 10q26.11
FAM45BP family with sequence similarity 45 member B, pseudogene FAM45B HT011 Xq26.1
KIAA1147 KIAA1147 LCHN 7q34


SMCR8, FLCN, C9orf72, FNIP1/2 and NPR2/3 contain divergent DENN domains, as described in PMID 23248642.