# Gene Family: Defensins, beta (DEFB)

**Beta defensin**: Beta defensins are a family of mammalian defensins. The beta defensins are antimicrobial peptides implicated in the resistance of epithelial surfaces to microbial colonization.
Defensins are 2-6 kDa, cationic, microbicidal peptides active against many Gram-negative and Gram-positive bacteria, fungi, and enveloped viruses, containing three pairs of intramolecular disulfide bonds. On the basis of their size and pattern of disulfide bonding, mammalian defensins are classified into alpha, beta and theta categories. Every mammalian species explored thus far has beta-defensins. In cows, as many as 13 beta-defensins exist in neutrophils. However, in other species, beta-defensins are more often produced by epithelial cells lining various organs (e.g. the epidermis, bronchial tree and genitourinary tract.
Human, rabbit and guinea-pig beta-defensins, as well as human beta-defensin-2 (hBD2), induce the activation and degranulation of mast cells, resulting in the release of histamine and prostaglandin D2.
[Source: Wikipedia]

## Genes contained within the family: 57

Approved Symbol | Approved Name | Previous Symbols | Synonyms | Chromosome |
---|---|---|---|---|

DEFB1 | defensin beta 1 | HBD-1, DEFB-1, DEFB101, HBD1, BD1, MGC51822 | 8p23.1 | |

DEFB4A | defensin beta 4A | DEFB102, DEFB2, DEFB4 | SAP1, HBD-2, DEFB-2 | 8p23.1 |

DEFB4B | defensin beta 4B | DEFB4P | 8p23.1 | |

DEFB103A | defensin beta 103A | DEFB3, DEFB103 | HBD-3, HBP-3, HBD3, HBP3, DEFB-3 | 8p23.1 |

DEFB103B | defensin beta 103B | 8p23.1 | ||

DEFB104A | defensin beta 104A | DEFB104 | DEFB4, DEFB-4 | 8p23.1 |

DEFB104B | defensin beta 104B | 8p23.1 | ||

DEFB105A | defensin beta 105A | DEFB105 | DEFB-5 | 8p23.1 |

DEFB105B | defensin beta 105B | 8p23.1 | ||

DEFB106A | defensin beta 106A | DEFB106 | DEFB-6 | 8p23.1 |

DEFB106B | defensin beta 106B | 8p23.1 | ||

DEFB107A | defensin beta 107A | DEFB107 | DEFB-7 | 8p23.1 |

DEFB107B | defensin beta 107B | HsT21816 | 8p23.1 | |

DEFB108A | defensin beta 108A | DEFB108, DEFB108P1 | DEFB-8 | 8p23.1 |

DEFB108B | defensin beta 108B | 11q13.4 | ||

DEFB108C | defensin beta 108C | DEFB108P2 | 8p23.1 | |

DEFB108D | defensin beta 108D (pseudogene) | DEFB108P3 | 8p23.1 | |

DEFB108E | defensin beta 108E (pseudogene) | DEFB108P4 | 8p23.1 | |

DEFB108F | defensin beta 108F (pseudogene) | DEFB108P5 | 4p16.1 | |

DEFB109A | defensin beta 109A (pseudogene) | DEFB109, DEFB109P1 | DEFB-9 | 8p23.1 |

DEFB109B | defensin beta 109B | DEFB109P1B | 8p23.1 | |

DEFB109C | defensin beta 109C | 8p23.1 | ||

DEFB109D | defensin beta 109D (pseudogene) | DEFB109P3 | 8p23.1 | |

DEFB109E | defensin beta 109E (pseudogene) | DEFB109P2 | 8p23.1 | |

DEFB109F | defensin beta 109F (pseudogene) | 12p13.31 | ||

DEFB110 | defensin beta 110 | DEFB-10, DEFB-11, DEFB111 | 6p12.3 | |

DEFB112 | defensin beta 112 | DEFB-12 | 6p12.3 | |

DEFB113 | defensin beta 113 | DEFB-13 | 6p12.3 | |

DEFB114 | defensin beta 114 | DEFB-14 | 6p12.3 | |

DEFB115 | defensin beta 115 | DEFB-15 | 20q11.21 | |

DEFB116 | defensin beta 116 | DEFB-16 | 20q11.21 | |

DEFB117 | defensin beta 117 (pseudogene) | DEFB-17 | 20q11.21 | |

DEFB118 | defensin beta 118 | C20orf63 | dJ1018D12.3, DEFB-18, ESC42 | 20q11.21 |

DEFB119 | defensin beta 119 | DEFB120 | DEFB-19, DEFB-20 | 20q11.21 |

DEFB121 | defensin beta 121 | DEFB-21 | 20q11.21 | |

DEFB122 | defensin beta 122 (pseudogene) | DEFB-22, DEFB122P | 20q11.21 | |

DEFB123 | defensin beta 123 | DEFB-23 | 20q11.21 | |

DEFB124 | defensin beta 124 | DEFB-24 | 20q11.21 | |

DEFB125 | defensin beta 125 | DEFB-25 | 20p13 | |

DEFB126 | defensin beta 126 | C20orf8 | bA530N10.1, DEFB-26 | 20p13 |

DEFB127 | defensin beta 127 | C20orf73 | bA530N10.2, DEF-27 | 20p13 |

DEFB128 | defensin beta 128 | DEFB-28 | 20p13 | |

DEFB129 | defensin beta 129 | C20orf87 | bA530N10.3, DEFB-29 | 20p13 |

DEFB130A | defensin beta 130A | DEFB130 | DEFB-30, DEFB30 | 8p23.1 |

DEFB130B | defensin beta 130B | 8p23.1 | ||

DEFB130C | defensin beta 130C (pseudogene) | 11q13.4 | ||

DEFB130D | defensin beta 130D (pseudogene) | 4p16.1 | ||

DEFB131A | defensin beta 131A | DEFB131 | DEFB-31 | 4p16.1 |

DEFB131B | defensin beta 131B | 11q13.4 | ||

DEFB131C | defensin beta 131C (pseudogene) | 8p23.1 | ||

DEFB131D | defensin beta 131D (pseudogene) | 8p23.1 | ||

DEFB131E | defensin beta 131E (pseudogene) | 8p23.1 | ||

DEFB132 | defensin beta 132 | RP5-1103G7.6, DEFB32 | 20p13 | |

DEFB133 | defensin beta 133 | 6p12.3 | ||

DEFB134 | defensin beta 134 | 8p23.1 | ||

DEFB135 | defensin beta 135 | 8p23.1 | ||

DEFB136 | defensin beta 136 | DEFB137 | 8p23.1 |