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Gene Family: Defensins, alpha (DEFA)

A subset of : Defensins

Alpha defensin: Alpha defensins are a family of mammalian defensin peptides. Defensins are 2-6 kDa, cationic, microbicidal peptides active against many Gram-negative and Gram-positive bacteria, fungi, and enveloped viruses, containing three pairs of intramolecular disulfide bonds. On the basis of their size and pattern of disulfide bonding, mammalian defensins are classified into alpha, beta and theta categories. Alpha-defensins, which have been identified in humans, monkeys and several rodent species, are particularly abundant in neutrophils, certain macrophage populations and Paneth cells of the small intestine. [Source: Wikipedia]

Genes contained within the family: 12

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
DEFA1 defensin alpha 1 DEF1, MRS, DEFA2 HNP-1 8p23.1
DEFA1A3 defensin alpha 1 and alpha 3, variable copy number locus DEFA1, DEFA3, DEFT1P 8p23.1
DEFA1B defensin alpha 1B 8p23.1
DEFA3 defensin alpha 3 DEF3 HNP-3 8p23.1
DEFA4 defensin alpha 4 DEF4 HP-4 8p23.1
DEFA5 defensin alpha 5 DEF5 HD-5 8p23.1
DEFA6 defensin alpha 6 HD-6, DEF6 8p23.1
DEFA7P defensin alpha 7, pseudogene DEFA7 8p23.1
DEFA8P defensin alpha 8, pseudogene DEFAP1 8p23.1
DEFA9P defensin alpha 9, pseudogene DEFAP2 8p23.1
DEFA10P defensin alpha 10, pseudogene 8p23.1
DEFA11P defensin alpha 11, pseudogene DEFAP3 8p23.1