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Gene Family: AAA ATPases (ATAD)

Also known as : "AAA ATPases (ATPases associated with diverse cellular activities)", "AAA+ ATPases", "ATPase family, AAA domain containing"
A subset of : ATPases

AAA proteins: AAA or AAA+ is an abbreviation for ATPases Associated with diverse cellular Activities. They share a common conserved module of approximately 230 amino acid residues. This is a large, functionally diverse protein family belonging to the AAA+ superfamily of ring-shaped P-loop NTPases, which exert their activity through the energy-dependent remodeling or translocation of macromolecules. AAA proteins couple chemical energy provided by ATP hydrolysis to conformational changes which are transduced into mechanical force exerted on a macromolecular substrate. AAA proteins are functionally and organizationally diverse, and vary in activity, stability, and mechanism. Members of the AAA family are found in all organisms and they are essential for many cellular functions. They are involved in processes such as DNA replication, protein degradation, membrane fusion, microtubule severing, peroxisome biogenesis, signal transduction and the regulation of gene expression. [Source: Wikipedia]

Genes contained within the family: 53

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
AFG3L1P AFG3 like matrix AAA peptidase subunit 1, pseudogene AFG3, AFG3L1 16q24.3
AFG3L2 AFG3 like matrix AAA peptidase subunit 2 SCA28 SPAX5 18p11.21
ATAD1 ATPase family, AAA domain containing 1 FLJ14600 10q23.31
ATAD2 ATPase family, AAA domain containing 2 PRO2000, DKFZp667N1320, MGC5254, MGC29843, CT137, ANCCA 8q24.13
ATAD2B ATPase family, AAA domain containing 2B KIAA1240 2p24.1-p23.3
ATAD3A ATPase family, AAA domain containing 3A FLJ10709 1p36.33
ATAD3B ATPase family, AAA domain containing 3B TOB3, KIAA1273 1p36.33
ATAD3C ATPase family, AAA domain containing 3C FLJ34599 1p36.33
ATAD5 ATPase family, AAA domain containing 5 C17orf41 FLJ12735, FRAG1, ELG1 17q11.2
BCS1L BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone Hs.6719, BCS, h-BCS, BJS 2q35
CHTF18 chromosome transmission fidelity factor 18 C16orf41 CHL12, C321D2.4, Ctf18 16p13.3
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin HSP78, SKD3, FLJ13152, ANKCLB 11q13.4
CLPP caseinolytic mitochondrial matrix peptidase proteolytic subunit 19p13.3
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 15q22.31
FIGN fidgetin, microtubule severing factor 2q24.3
FIGNL1 fidgetin like 1 7p12.2
FIGNL2 fidgetin like 2 12q13.13
IQCA1 IQ motif containing with AAA domain 1 IQCA FLJ22527, DRC11 2q37.2-q37.3
KATNAL1 katanin catalytic subunit A1 like 1 MGC2599 13q12.3
KATNAL2 katanin catalytic subunit A1 like 2 MGC33211, DKFZP667C165 18q21.1
KATNA1 katanin catalytic subunit A1 6q25.1
LONP1 lon peptidase 1, mitochondrial PRSS15 LonHS, hLON, PIM1 19p13.2
LONP2 lon peptidase 2, peroxisomal MGC4840, LONP, LONPL 16q12.1
MDN1 midasin AAA ATPase 1 KIAA0301, Rea1 6q15
NSF N-ethylmaleimide sensitive factor, vesicle fusing ATPase SKD2, SEC18 17q21.31
NVL nuclear VCP-like NVL2 1q42.11
ORC1 origin recognition complex subunit 1 ORC1L HSORC1, PARC1 1p32.3
ORC4 origin recognition complex subunit 4 ORC4L HsORC4, Orc4p 2q23.1
PEX1 peroxisomal biogenesis factor 1 ZWS1, ZWS 7q21.2
PEX6 peroxisomal biogenesis factor 6 PXAAA1, PAF-2 6p21.1
PSMC1 proteasome 26S subunit, ATPase 1 S4, p56 14q32.11
PSMC2 proteasome 26S subunit, ATPase 2 MSS1, S7, Nbla10058 7q22.1
PSMC3 proteasome 26S subunit, ATPase 3 TBP1, TBP-1 11p11.2
PSMC4 proteasome 26S subunit, ATPase 4 MIP224 TBP7, S6, MGC8570, MGC13687, MGC23214, TBP-7 19q13.11-q13.13
PSMC5 proteasome 26S subunit, ATPase 5 SUG1, p45/SUG, TBP10, p45, S8, TRIP1, SUG-1 17q23.3
PSMC6 proteasome 26S subunit, ATPase 6 p42 14q22.1
RFC1 replication factor C subunit 1 A1, PO-GA, RFC140, MHCBFB 4p14
RFC2 replication factor C subunit 2 A1, RFC40 7q11.23
RFC3 replication factor C subunit 3 RFC38, MGC5276 13q13.2
RFC4 replication factor C subunit 4 A1, RFC37 3q27.3
RFC5 replication factor C subunit 5 RFC36 12q24.23
RUVBL1 RuvB like AAA ATPase 1 TIP49, NMP238, RVB1, TIP49a, Pontin52, ECP54, TIH1, Rvb1, INO80H 3q21.3
RUVBL2 RuvB like AAA ATPase 2 RVB2, TIP48, TIP49b, Reptin52, ECP51, TIH2, INO80J, Rvb2 19q13.33
SPAST spastin SPG4 FSP2, ADPSP, KIAA1083 2p22.3
SPATA5 spermatogenesis associated 5 SPAF, AFG2 4q28.1
SPATA5L1 spermatogenesis associated 5 like 1 MGC5347, FLJ12286 15q21.1
SPG7 SPG7, paraplegin matrix AAA peptidase subunit CMAR CAR, SPG5C 16q24.3
TRIP13 thyroid hormone receptor interactor 13 16E1BP 5p15.33
VCP valosin containing protein IBMPFD, p97, CDC48, TERA 9p13.3
VPS4A vacuolar protein sorting 4 homolog A VPS4, VPS4-1, FLJ22197, SKD2, SKD1, SKD1A 16q23.1
VPS4B vacuolar protein sorting 4 homolog B SKD1 VPS4-2, SKD1B 18q21.33
WRNIP1 Werner helicase interacting protein 1 WHIP, FLJ22526, bA420G6.2 6p25.2
YME1L1 YME1 like 1 ATPase 10p12.1

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