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Gene Family: Sulfatases (ARS)

Sulfatase: Sulfatases EC 3.1.6. are enzymes of the esterase class that catalyze the hydrolysis of sulfate esters. These may be found on a range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. In the latter case the resultant N-sulfates can also be termed sulfamates. Sulfatases play important roles in the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodelling sulfated glycosaminoglycans in the extracellular space. Together with sulfotransferases, sulfatases form the major catalytic machinery for the synthesis and breakage of sulfate esters. [Source: Wikipedia]

Genes contained within the family: 18

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
ARSA arylsulfatase A 22q13.33
ARSB arylsulfatase B 5q14.1
STS steroid sulfatase ARSC1 ARSC Xp22.31
ARSC2 arylsulfatase C, isozyme F ARSC X
ARSD arylsulfatase D Xp22.33
ARSE arylsulfatase E (chondrodysplasia punctata 1) CDPX, CDPX1 Xp22.33
ARSF arylsulfatase F Xp22.33
ARSG arylsulfatase G KIAA1001 17q24.2
ARSH arylsulfatase family member H Xp22.33
ARSI arylsulfatase family member I FLJ16069, SPG66 5q32
ARSJ arylsulfatase family member J FLJ23548 4q26
ARSK arylsulfatase family member K DKFZp313G1735, TSULF 5q15
GALNS galactosamine (N-acetyl)-6-sulfatase GAS, GALNAC6S 16q24.3
GNS glucosamine (N-acetyl)-6-sulfatase 12q14.3
IDS iduronate 2-sulfatase SIDS Xq28
SGSH N-sulfoglucosamine sulfohydrolase HSS, MPS3A, SFMD 17q25.3
SULF1 sulfatase 1 KIAA1077, SULF-1, hSulf-1 8q13.2-q13.3
SULF2 sulfatase 2 KIAA1247, HSULF-2, SULF-2 20q13.12