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Gene Family: Armadillo repeat containing (ARMC)

Also known as : "ARM repeat containing"

Armadillo repeat proteins: Armadillo repeat is the name of a characteristic, repetitive amino acid sequence found in β-catenin and many other proteins, like α-importin, plakoglobin,or adenomatous polyposis coli (APC). Its name derives from the historical name of the β-catenin gene in the fruitfly Drosophila: where they were first discovered. Armadillo repeats are approximately 40 amino acids long and proteins that contain them usually have many tandemly repeated copies. These tandem repeats usually fold together to form a single, rigid protein domain called the armadillo (ARM) domain. Because ARM domains can consist of a variable number of repeats, they are a good example of solenoid protein domains. The best characterized example of armadillo domains is found in β-catenin. β-catenin is a protein involved in linking cadherin cell adhesion proteins to the cytoskeleton, but the Armadillo repeat is found in a wide range of proteins with other functions. This type of protein domain is important in transducing WNT signals during embryonic development. [Source: HGNC]

Genes contained within the family: 43

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
ANKAR ankyrin and armadillo repeat containing FLJ25415 2q32.2
APC APC, WNT signaling pathway regulator DP2, DP3, DP2.5, PPP1R46 5q22.2
APC2 APC2, WNT signaling pathway regulator APCL 19p13.3
ARMCX1 armadillo repeat containing X-linked 1 ALEX1, GASP7 Xq22.1
ARMCX2 armadillo repeat containing X-linked 2 ALEX2, KIAA0512, GASP9 Xq22.1
ARMCX3 armadillo repeat containing X-linked 3 ALEX3, GASP6 Xq22.1
ARMCX4 armadillo repeat containing X-linked 4 CXorf35 MGC40053, GASP4 Xq22.1
ARMCX5 armadillo repeat containing X-linked 5 FLJ12969, GASP5 Xq22.1
ARMCX6 armadillo repeat containing X-linked 6 FLJ20811, GASP10 Xq22.1
ARMC1 armadillo repeat containing 1 FLJ10511, Arcp 8q13.1
ARMC2 armadillo repeat containing 2 DKFZp434P0714, bA787I22.1 6q21
ARMC3 armadillo repeat containing 3 FLJ32827, CT81 10p12.2
ARMC4 armadillo repeat containing 4 FLJ10817, FLJ10376, DKFZP434P1735, CILD23 10p12.1
ARMC5 armadillo repeat containing 5 FLJ13063 16p11.2
ARMC6 armadillo repeat containing 6 MGC19595 19p13.11
ARMC7 armadillo repeat containing 7 FLJ22160 17q25.1
ARMC8 armadillo repeat containing 8 HSPC056, DKFZP434A043, GID5, VID28 3q22.3
ARMC9 armadillo repeat containing 9 FLJ12584, KIAA1868, ARM, KU-MEL-1 2q37.1
ARMC10 armadillo repeat containing 10 MGC3195, SVH 7q22.1
ARMC12 armadillo repeat containing 12 C6orf81 FLJ25390 6p21.31
THADA THADA, armadillo repeat containing GITA, FLJ21877, ARMC13, KIAA1767 2p21
ARVCF ARVCF, delta catenin family member 22q11.21
BHLHB9 basic helix-loop-helix family member b9 p60TRP, KIAA1701, GASP3 Xq22.1
CTNNB1 catenin beta 1 CTNNB beta-catenin, armadillo 3p22.1
CTNND1 catenin delta 1 CTNND KIAA0384, p120, p120cas, p120ctn 11q12.1
CTNND2 catenin delta 2 NPRAP, GT24 5p15.2
GPRASP1 G protein-coupled receptor associated sorting protein 1 GASP, GASP1 Xq22.1
GPRASP2 G protein-coupled receptor associated sorting protein 2 GASP2, FLJ37327 Xq22.1
JUP junction plakoglobin CTNNG DP3, PDGB, PKGB, DPIII 17q21.2
KPNA1 karyopherin subunit alpha 1 SRP1, RCH2, NPI-1, IPOA5 3q21.1
KPNA2 karyopherin subunit alpha 2 RCH1 SRP1alpha, IPOA1, QIP2 17q24.2
KPNA3 karyopherin subunit alpha 3 SRP1gamma, SRP4, hSRP1, IPOA4 13q14.2
KPNA4 karyopherin subunit alpha 4 QIP1, SRP3, IPOA3, MGC12217, MGC26703 3q25.33
KPNA5 karyopherin subunit alpha 5 SRP6, IPOA6 6q22.1
KPNA6 karyopherin subunit alpha 6 IPOA7, KPNA7, MGC17918, FLJ11249 1p35.2
KPNA7 karyopherin subunit alpha 7 IPOA8 7q22.1
KPNB1 karyopherin subunit beta 1 NTF97, IPOB, MGC2155, MGC2156, MGC2157, IMB1, Impnb, IPO1 17q21.32
PKP1 plakophilin 1 B6P 1q32.1
PKP2 plakophilin 2 12p11.21
PKP3 plakophilin 3 11p15.5
PKP4 plakophilin 4 p0071 2q24.1
RAP1GDS1 Rap1 GTPase-GDP dissociation stimulator 1 SmgGDS 4q23
SPAG6 sperm associated antigen 6 Repro-SA-1, pf16, CT141 10p12.2