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Gene Family: Alkylation repair homologs (ALKBH)

Alkylation repair homologs: Members of this family are homologous to AlkB, an E.coli enzyme that repairs alkylated DNA and RNA.The 9 human homologs are all members of the alpha-ketoglutarate and FE(II)-dependent dioxygenase superfamily. [Source: HGNC]

Genes contained within the family: 9

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
ALKBH1 alkB homolog 1, histone H2A dioxygenase ALKBH hABH, alkB, ABH 14q24.3
ALKBH2 alkB homolog 2, alpha-ketoglutarate dependent dioxygenase MGC90512, ABH2 12q24.11
ALKBH3 alkB homolog 3, alpha-ketoglutaratedependent dioxygenase DEPC-1 11p11.2
ALKBH4 alkB homolog 4, lysine demethylase FLJ20013 7q22.1
ALKBH5 alkB homolog 5, RNA demethylase OFOXD1 FLJ20308 17p11.2
ALKBH6 alkB homolog 6 MGC15677 19q13.12
ALKBH7 alkB homolog 7 SPATA11 MGC10974 19p13.3
ALKBH8 alkB homolog 8, tRNA methyltransferase MGC10235, TRM9, TRMT9A 11q22.3
FTO FTO, alpha-ketoglutarate dependent dioxygenase ALKBH9, KIAA1752, MGC5149 16q12.2