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Gene Family: Alcohol dehydrogenases (ADH)

Alcohol dehydrogenase: Alcohol dehydrogenases ( ADH ) ( EC ) are a group of dehydrogenase enzymes that occur in many organisms and facilitate the interconversion between alcohols and aldehydes or ketones with the reduction of nicotinamide adenine dinucleotide (NAD + to NADH). In humans and many other animals, they serve to break down alcohols that otherwise are toxic, and they also participate in generation of useful aldehyde, ketone, or alcohol groups during biosynthesis of various metabolites. In yeast, plants, and many bacteria, some alcohol dehydrogenases catalyze the opposite reaction as part of fermentation to ensure a constant supply of NAD +. [Source: Wikipedia]

Genes contained within the family: 8

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
ADHFE1 alcohol dehydrogenase, iron containing 1 ADHFe1, FLJ32430 8q13.1
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide ADH1 4q23
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide ADH2 4q23
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide ADH3 4q23
ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide ADH-2 4q23
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide FDH ADH-3, ADHX, GSNOR 4q23
ADH6 alcohol dehydrogenase 6 (class V) ADH-5 4q23
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide ADH-4 4q23