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Gene Family: Guanylate cyclase receptors (GUCY2)

Also known as : "Receptor Guanylate Cyclase family", "RGC family", "Membrane-bound guanylate cyclases", "Membrane bound guanylyl cyclases"

Guanylate cyclase receptors: Membrane bound guanylyl cyclases include an external ligand-binding domain (e.g., for peptide hormones such as BNP and ANP), a transmembrane domain, and an internal catalytic domain homologous to adenylate cyclases. [Source: Wikipedia]

Genes contained within the family: 7

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
NPR1 natriuretic peptide receptor 1 ANPRA, NPRA ANPa, GUCY2A 1q21.3
NPR2 natriuretic peptide receptor 2 ANPRB, NPRB, AMDM ANPb, GUCY2B 9p13.3
GUCY2C guanylate cyclase 2C GUC2C STAR 12p12.3
GUCY2D guanylate cyclase 2D, retinal CORD6, LCA, GUC2D, GUC1A4 retGC, RETGC-1, ROS-GC1, CYGD, LCA1 17p13.1
GUCY2EP guanylate cyclase 2E, pseudogene GUCY2E GC-E 11q13.5
GUCY2F guanylate cyclase 2F, retinal GUC2DL, GC-F, RetGC-2, ROS-GC2, CYGF Xq22.3-q23
GUCY2GP guanylate cyclase 2G, pseudogene GUCY2G 10q25.2