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Gene Family: Aquaporins (AQP)

A subset of : Porins

Aquaporin: Aquaporins are integral membrane proteins from a larger family of major intrinsic proteins (MIP) that form pores in the membrane of biological cells. Genetic defects involving aquaporin genes have been associated with several human diseases. The 2003 Nobel Prize in Chemistry was awarded jointly to Peter Agre for the discovery of aquaporins, and Roderick MacKinnon for his work on the structure and mechanism of potassium channels. The plasma membranes of a variety of different animal and plant cells contain aquaporins through which water can flow more rapidly inside the cell than by diffusing through the phospholipid bilayer. [Source: Wikipedia]

Genes contained within the family: 14

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
MIP major intrinsic protein of lens fiber MP26, AQP0, LIM1 12q13
AQP1 aquaporin 1 (Colton blood group) CO CHIP28 7p14.3
AQP2 aquaporin 2 12q13.12
AQP3 aquaporin 3 (Gill blood group) GIL 9p13.3
AQP4 aquaporin 4 MIWC 18q11.2
AQP5 aquaporin 5 12q13.12
AQP6 aquaporin 6 AQP2L 12q13.12
AQP7 aquaporin 7 AQP7L AQP9, AQPap 9p13.3
AQP8 aquaporin 8 16p12.1
AQP9 aquaporin 9 SSC1, HsT17287 15q21.3
AQP10 aquaporin 10 1q21.3
AQP11 aquaporin 11 11q14.1
AQP12A aquaporin 12A AQP12 2q37.3
AQP12B aquaporin 12B INSSA3 2q37.3

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