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Gene Family: Inositol 1,4,5-triphosphate receptors (ITPR)

Also known as : "InsP3R", "Inositol triphosphate receptors"

Inositol trisphosphate receptor: Inositol trisphosphate receptor ( InsP3R ) is a membrane glycoprotein complex acting as a Ca 2+ channel activated by inositol trisphosphate (InsP3). InsP3R is very diverse among organisms, and is necessary for the control of cellular and physiological processes including cell division, cell proliferation, apoptosis, fertilization, development, behavior, learning and memory. Inositol triphosphate receptor represents a dominant second messenger leading to the release of Ca 2+ from intracellular store sites. There is strong evidence suggesting that the InsP3R plays an important role in the conversion of external stimuli to intracellular Ca 2+ signals characterized by complex patterns relative to both space and time. For example, Ca 2+ waves and oscillations. The InsP3 receptor was first purified from rat cerebellum by neuroscientists Surachai Supattapone and Solomon Snyder at Johns Hopkins University School of Medicine. [Source: Wikipedia]

Genes contained within the family: 3

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
ITPR1 inositol 1,4,5-trisphosphate receptor type 1 SCA15, SCA16, SCA29 Insp3r1, IP3R1, ACV, PPP1R94 3p26.1
ITPR2 inositol 1,4,5-trisphosphate receptor type 2 IP3R2, CFAP48 12p11.23
ITPR3 inositol 1,4,5-trisphosphate receptor type 3 IP3R3 6p21.31