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Gene Family: Potassium voltage-gated channel subfamily J (KCNJ)

Also known as : "Kir", "IRK", "Inward-rectifier potassium ion channels", "Inwardly-rectifying potassium channels", "Potassium channels, inwardly rectifying subfamily J"

Inward-rectifier potassium ion channel: Inwardly rectifying potassium channels ( Kir, IRK ) are a specific subset of potassium selective ion channels. To date, seven subfamilies have been identified in various mammalian cell types and they are also found in plants. They are the targets of multiple toxins, and malfunction of the channels has been implicated in several diseases. [Source: Wikipedia]

Genes contained within the family: 16

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
KCNJ1 potassium voltage-gated channel subfamily J member 1 Kir1.1, ROMK1 11q24.3
KCNJ2 potassium voltage-gated channel subfamily J member 2 Kir2.1, IRK1, LQT7 17q24.3
KCNJ3 potassium voltage-gated channel subfamily J member 3 Kir3.1, GIRK1, KGA 2q24.1
KCNJ4 potassium voltage-gated channel subfamily J member 4 Kir2.3, HIR, HRK1, hIRK2, IRK3 22q13.1
KCNJ5 potassium voltage-gated channel subfamily J member 5 Kir3.4, CIR, KATP1, GIRK4, LQT13 11q24.3
KCNJ6 potassium voltage-gated channel subfamily J member 6 KCNJ7 Kir3.2, GIRK2, KATP2, BIR1, hiGIRK2 21q22.13
KCNJ8 potassium voltage-gated channel subfamily J member 8 Kir6.1 12p12.1
KCNJ9 potassium voltage-gated channel subfamily J member 9 Kir3.3, GIRK3 1q23.2
KCNJ10 potassium voltage-gated channel subfamily J member 10 Kir4.1, Kir1.2 1q23.2
KCNJ11 potassium voltage-gated channel subfamily J member 11 Kir6.2, BIR 11p15.1
KCNJ12 potassium voltage-gated channel subfamily J member 12 KCNJN1 Kir2.2, Kir2.2v, IRK2, hIRK1 17p11.2
KCNJ13 potassium voltage-gated channel subfamily J member 13 Kir7.1, Kir1.4, LCA16 2q37.1
KCNJ14 potassium voltage-gated channel subfamily J member 14 Kir2.4, IRK4 19q13.33
KCNJ15 potassium voltage-gated channel subfamily J member 15 Kir4.2, Kir1.3, IRKK 21q22.13-q22.2
KCNJ16 potassium voltage-gated channel subfamily J member 16 Kir5.1, BIR9 17q24.3
KCNJ18 potassium voltage-gated channel subfamily J member 18 KIR2.6, TTPP2 17p11.2