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Gene Family: CTLH complex

Also known as : "C-terminal to LisH complex", "Muskelin/RanBP9/CTLH complex", "GID complex", "MRCTLH complex"

CTLH complex:: The yeast homologue of this complex (the GID complex) functions as an E3 ubiquitin ligase that targets enzymes of the gluconeogenesis pathway. While the CTLH complex E3 ubiquitin ligase activity and substrates still remain to be characterized, the high level of conservation between the complexes in yeast and mammals infers that the CTLH complex could also serve to promote the degradation of specific substrates through ubiquitination. With the exception of ARMC8, a striking feature is the shared presence of LisH and CTLH domains amongst the complex members. [Source: Salemi et al, 2017]

Genes contained within the family: 7

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
ARMC8 armadillo repeat containing 8 HSPC056, DKFZP434A043, GID5, VID28 3q22.3
GID8 GID complex subunit 8 homolog C20orf11 FLJ20602, bA305P22.1, TWA1 20q13.33
MAEA macrophage erythroblast attacher EMP, GID9 4p16.3
MKLN1 muskelin 1 TWA2 7q32.3
RANBP9 RAN binding protein 9 RanBPM 6p23
RMND5A required for meiotic nuclear division 5 homolog A FLJ13910, RMD5, GID2, GID2A, p44CTLH 2p11.2
SWSAP1 SWIM-type zinc finger 7 associated protein 1 C19orf39 FLJ35119, ZSWIM7AP1, SWS1AP1 19p13.2

Comments

WDR26 may encode a subunit of this complex (Salemi et al, 2017)

Publications

28668087,24143168,24143168