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Gene Family: Spliceosomal C complex

Also known as : "catalytic spliceosome"
A subset of : Major spliceosome

Spliceosomal C complex:: After additional RNP rearrangements, the C complex catalyses the second step of splicing, resulting in the ligation of the 5' and 3' exons and release of the intron in the form of a lariat. [Source: Sidarovic et al, 2017]

Family contains the following subsets

Genes contained within the family: 53

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
AQR aquarius intron-binding spliceosomal factor KIAA0560, fSAP164, IBP160 15q14
BCAS2 BCAS2, pre-mRNA processing factor DAM1, SPF27, Snt309 1p13.2
BUD31 BUD31 homolog G10 YCR063W, EDG-2, EDG2, fSAP17, Cwc14 7q22.1
CACTIN cactin, spliceosome C complex subunit C19orf29 NY-REN-24, fSAPc, cactin 19p13.3
CCDC12 coiled-coil domain containing 12 MGC23918 3p21.31
CDC5L cell division cycle 5 like PCDC5RP, hCDC5, CEF1, CDC5 6p21.1
CDC40 cell division cycle 40 PRP17, EHB3, PRPF17, FLJ10564 6q21
CDK10 cyclin dependent kinase 10 PISSLRE 16q24.3
CRNKL1 crooked neck pre-mRNA splicing factor 1 CRN, CLF, SYF3, Clf1 20p11.23
CTNNBL1 catenin beta like 1 C20orf33 FLJ21108, P14L, P14, NAP, NYD-SP19 20q11.23
CWC15 CWC15 spliceosome associated protein homolog C11orf5, HSPC148, Cwf15, AD002 11q21
CWC22 CWC22 spliceosome associated protein homolog KIAA1604, EIF4GL, fSAPb, NCM 2q31.3
CWC27 CWC27 spliceosome associated protein homolog SDCCAG10 NY-CO-10, SDCCAG-10 5q12.3
CXorf56 chromosome X open reading frame 56 FLJ22965 Xq24
DDX41 DEAD-box helicase 41 ABS, MGC8828 5q35.3
DHX8 DEAH-box helicase 8 DDX8 HRH1, PRP22, PRPF22, Dhr2 17q21.31
DHX16 DEAH-box helicase 16 DDX16 DBP2, Prp2, PRPF2 6p21.33
DHX35 DEAH-box helicase 35 C20orf15, DDX35 FLJ22759, KAIA0875 20q11.23-q12
EFTUD2 elongation factor Tu GTP binding domain containing 2 U5-116KD, Snrp116, Snu114, SNRNP116 17q21.31
FAM32A family with sequence similarity 32 member A DKFZP586O0120, OTAG-12 19p13.11
FAM50A family with sequence similarity 50 member A DXS9928E, XAP5, HXC-26, 9F Xq28
FRA10AC1 FRA10A associated CGG repeat 1 C10orf4 10q23.33
GPATCH1 G-patch domain containing 1 GPATC1 ECGP, FLJ10206, FLJ38686 19q13.11
GPKOW G-patch domain and KOW motifs T54, GPATC5, GPATCH5, Spp2 Xp11.23
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) HNRPC hnRNPC 14q11.2
HSPA8 heat shock protein family A (Hsp70) member 8 HSPA10 HSC71, HSC70, HSP73 11q24.1
ISY1 ISY1 splicing factor homolog KIAA1160, fSAP33 3q21.3
LENG1 leukocyte receptor cluster member 1 19q13.42
NOSIP nitric oxide synthase interacting protein CGI-25 19q13.33
PLRG1 pleiotropic regulator 1 PRL1, Prp46, PRPF46, Cwc1, TANGO4 4q31.3
PPIE peptidylprolyl isomerase E CyP-33, MGC3736, MGC111222 1p34.2
PPIG peptidylprolyl isomerase G CARS-Cyp, SRCyp, SCAF10 2q31.1
PPIL1 peptidylprolyl isomerase like 1 CYPL1 6p21.2
PPIL3 peptidylprolyl isomerase like 3 CyPJ 2q33.1
PPWD1 peptidylprolyl isomerase domain and WD repeat containing 1 KIAA0073 5q12.3
PRPF8 pre-mRNA processing factor 8 RP13 PRPC8, Prp8, hPrp8, SNRNP220 17p13.3
PRPF18 pre-mRNA processing factor 18 hPrp18 10p13
PRPF19 pre-mRNA processing factor 19 PRP19 UBOX4, NMP200, PSO4, hPSO4, SNEV 11q12.2
RBM22 RNA binding motif protein 22 FLJ10290, ZC3H16, fSAP47, Cwc2 5q33.1
RNF113A ring finger protein 113A ZNF183 RNF113, Cwc24 Xq24
RNU5A-1 RNA, U5A small nuclear 1 RNU5C, RNU5A U5A, U5B1 15q22.31
RNU6-1 RNA, U6 small nuclear 1 RNU6A U6, U6-1 15q23
SAP18 Sin3A associated protein 18 SAP18p, 2HOR0202, MGC27131 13q12.11
SDE2 SDE2 telomere maintenance homolog C1orf55 FLJ35382 1q42.12
SLU7 SLU7 homolog, splicing factor 9G8 5q33.3
SNRNP40 small nuclear ribonucleoprotein U5 subunit 40 WDR57 PRP8BP, SPF38, PRPF8BP, HPRP8BP 1p35.2
SNRNP200 small nuclear ribonucleoprotein U5 subunit 200 ASCC3L1, RP33 U5-200KD, HELIC2, KIAA0788, BRR2 2q11.2
SNW1 SNW domain containing 1 SKIIP NCoA-62, SKIP, Prp45, PRPF45, Bx42, SKIP1, FUN20 14q24.3
SRRM2 serine/arginine repetitive matrix 2 SRm300, SRL300, KIAA0324, Cwc21 16p13.3
SYF2 SYF2 pre-mRNA splicing factor CBPIN p29, DKFZp564O2082, NTC31, fSAP29 1p36.11
WDR83 WD repeat domain 83 MORG1 19p13.13
XAB2 XPA binding protein 2 HCNP, HCRN, SYF1, NTC90 19p13.3
ZNF830 zinc finger protein 830 CCDC16 MGC20398, OMCG1 17q12

Genes contained within subsets


A version of the U5 snRNP complex is present in the C complex, but is lacking the proteins encoded by PRPF6, DDX23 and TXNL4A.