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Gene Family: Armadillo-like helical domain containing (ARMH)

Also known as : "IPR011989", "ARM-like", "Armadillo-like helical superfamily"

Family contains the following subsets

Genes contained within the family: 244

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
ACRBP acrosin binding protein SP32, OY-TES-1, CT23 12p13.31
AGBL1 ATP/GTP binding protein like 1 FLJ32310, CCP4 15q25.3
AGTPBP1 ATP/GTP binding protein 1 KIAA1035, Nna1, CCP1 9q21.33
API5 apoptosis inhibitor 5 AAC-11, API5L1, AAC11 11p12
AP5B1 adaptor related protein complex 5 subunit beta 1 PP1030, AP-5, DKFZp761E198 11q13.1
AP5Z1 adaptor related protein complex 5 subunit zeta 1 KIAA0415 SPG48, zeta 7p22.1
ARFGEF1 ADP ribosylation factor guanine nucleotide exchange factor 1 DKFZP434L057, BIG1, ARFGEP1, p200 8q13.2
ARFGEF2 ADP ribosylation factor guanine nucleotide exchange factor 2 BIG2 20q13.13
ARFGEF3 ARFGEF family member 3 C6orf92, KIAA1244 dJ171N11.1, BIG3, PPP1R33 6q23.3-q24.1
ARID1A AT-rich interaction domain 1A C1orf4, SMARCF1 B120, P270, C10rf4, BAF250, BAF250a 1p36.11
ARID1B AT-rich interaction domain 1B KIAA1235, ELD/OSA1, p250R, BAF250b, DAN15, 6A3-5 6q25.3
ARID2 AT-rich interaction domain 2 KIAA1557, DKFZp686G052, FLJ30619, BAF200 12q12
ARMH1 armadillo-like helical domain containing 1 NCRNA00082, C1orf228 MGC33556, p40 1p34.1
ARMH2 armadillo-like helical domain containing 2 C6orf229 6p22.3
ARMH3 armadillo-like helical domain containing 3 C10orf76 FLJ13114 10q24.32
ARMH4 armadillo-like helical domain containing 4 C14orf37 UT2 14q23.1
ARVCF ARVCF, delta catenin family member 22q11.21
ATM ATM serine/threonine kinase ATA, ATDC, ATC, ATD TEL1, TELO1 11q22.3
ATP6V1H ATPase H+ transporting V1 subunit H CGI-11, SFD, VMA13, SFDalpha, SFDbeta 8q11.23
ATR ATR serine/threonine kinase FRP1, SCKL, SCKL1, MEC1 3q23
ATRIP ATR interacting protein FLJ12343, MGC20625, MGC21482, MGC26740 3p21.31
ATXN10 ataxin 10 SCA10 E46L, FLJ37990 22q13.31
BTAF1 B-TFIID TATA-box binding protein associated factor 1 TAFII170, TAF172, MOT1, TAF-172, TAF(II)170 10q23.32
CAB39 calcium binding protein 39 CGI-66, MO25 2q37.1
CAB39L calcium binding protein 39 like bA103J18.3, FLJ12577, MO2L 13q14.2
CAND1 cullin associated and neddylation dissociated 1 TIP120A, DKFZp434M1414, KIAA0829, TIP120 12q14.3-q15
CAND2 cullin associated and neddylation dissociated 2 (putative) TIP120B, KIAA0667, Tp120b 3p25.2
CEBPZ CCAAT enhancer binding protein zeta CBF2, CTF2 2p22.2
CFAP69 cilia and flagella associated protein 69 C7orf63 FLJ21062, FAP69 7q21.13
CHIC1 cysteine rich hydrophobic domain 1 BRX Xq13.2
CIP2A cell proliferation regulating inhibitor of protein phosphatase 2A KIAA1524 3q13.13
CNOT1 CCR4-NOT transcription complex subunit 1 NOT1 CDC39, NOT1H, KIAA1007, AD-005 16q21
CNOT9 CCR4-NOT transcription complex subunit 9 RQCD1 RCD1, RCD1+, CT129, CAF40 2q35
CTNNBL1 catenin beta like 1 C20orf33 FLJ21108, P14L, P14, NAP, NYD-SP19 20q11.23
CUL9 cullin 9 H7AP1, KIAA0708, PARC 6p21.1
DAAM1 dishevelled associated activator of morphogenesis 1 KIAA0666 14q23.1
DAAM2 dishevelled associated activator of morphogenesis 2 KIAA0381 6p21.2
DCAF1 DDB1 and CUL4 associated factor 1 VPRBP KIAA0800, MGC102804 3p21.2
DIAPH1 diaphanous related formin 1 DFNA1 hDIA1, LFHL1 5q31.3
DIAPH2 diaphanous related formin 2 POF, DIA, POF2, DIA2 Xq21.33
DIAPH3 diaphanous related formin 3 AUNA1 DRF3, FLJ34705, AN, NSDAN 13q21.2
DNAJC13 DnaJ heat shock protein family (Hsp40) member C13 RME8, KIAA0678 3q22.1
DOCK1 dedicator of cytokinesis 1 DOCK180, ced5 10q26.2
DOCK2 dedicator of cytokinesis 2 KIAA0209 5q35.1
DOCK3 dedicator of cytokinesis 3 KIAA0299, MOCA, PBP 3p21.2
DOCK8 dedicator of cytokinesis 8 FLJ00026, FLJ00152, ZIR8, FLJ00346 9p24.3
DOCK9 dedicator of cytokinesis 9 KIAA1058, ZIZ1 13q32.3
DOCK10 dedicator of cytokinesis 10 ZIZ3, KIAA0694 2q36.2
DOCK11 dedicator of cytokinesis 11 FLJ32122, FLJ43653, ZIZ2, ACG Xq24
DOHH deoxyhypusine hydroxylase HLRC1 MGC4293 19p13.3
DYM dymeclin FLJ20071, DMC, SMC 18q21.1
EFR3A EFR3 homolog A KIAA0143 8q24.22
EFR3B EFR3 homolog B KIAA0953 FLJ37871 2p23.3
EIF3A eukaryotic translation initiation factor 3 subunit A EIF3, EIF3S10 eIF3-theta, eIF3-p170, KIAA0139, eIF3a, TIF32 10q26.11
EIF3B eukaryotic translation initiation factor 3 subunit B EIF3S9 PRT1, eIF3b 7p22.3
EIF3CL eukaryotic translation initiation factor 3 subunit C like 16p12.1
EIF3D eukaryotic translation initiation factor 3 subunit D EIF3S7 eIF3-p66, eIF3-zeta, eIF3d 22q12.3
EIF3M eukaryotic translation initiation factor 3 subunit M PCID1 hfl-B5, FLJ29030, GA17, eIF3m, TANGO7 11p13
EXOC3L2 exocyst complex component 3 like 2 FLJ36147, XTP7 19q13.32
FAM160B1 family with sequence similarity 160 member B1 KIAA1600 bA106M7.3 10q25.3
FAM160B2 family with sequence similarity 160 member B2 RAI16 FLJ21801 8p21.3
FANCD2 FA complementation group D2 FACD, FANCD FAD, FA-D2 3p25.3
FHOD1 formin homology 2 domain containing 1 FHOS 16q22.1
FHOD3 formin homology 2 domain containing 3 FHOS2, KIAA1695, FLJ22297, FLJ22717 18q12.2
FMNL1 formin like 1 C17orf1B, FMNL C17orf1 17q21.31
FMNL2 formin like 2 FHOD2 KIAA1902 2q23.3
FMNL3 formin like 3 DKFZp762B245, MGC45819, WBP3 12q13.12
FOCAD focadhesin KIAA1797 FLJ20375 9p21.3
FRY FRY microtubule binding protein C13orf14 bA37E23.1, 13CDNA73, CG003 13q13.1
FRYL FRY like transcription coactivator KIAA0826 DKFZp686E205, AF4p12, MOR2 4p11
FTSJ3 FtsJ RNA methyltransferase homolog 3 SPB1 17q23.3
GIGYF1 GRB10 interacting GYF protein 1 PERQ1 GYF1 7q22.1
HEATR1 HEAT repeat containing 1 FLJ10359, BAP28, UTP10 1q43
HEATR3 HEAT repeat containing 3 FLJ20718 16q12.1
HEATR4 HEAT repeat containing 4 MGC48595 14q24.3
HEATR5A HEAT repeat containing 5A C14orf125 DKFZP434I1735 14q12
HEATR5B HEAT repeat containing 5B KIAA1414, DKFZp686P15184 2p22.2
HEATR6 HEAT repeat containing 6 ABC1, FLJ22087 17q23.1
HEATR9 HEAT repeat containing 9 C17orf66 FLJ32830 17q12
HECTD1 HECT domain E3 ubiquitin protein ligase 1 KIAA1131 14q12
HGH1 HGH1 homolog C8orf30A, FAM203B, C8orf30B, FAM203A FLJ40907, LOC51236, Brp16 8q24.3
HSF2BP heat shock transcription factor 2 binding protein 21q22.3
HSPBP1 HSPA (Hsp70) binding protein 1 HspBP1, FES1 19q13.42
HTT huntingtin HD IT15 4p16.3
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase Ib772, KIAA0312, UREB1 Xp11.22
IFRD1 interferon related developmental regulator 1 PC4, TIS7 7q31.1
IFRD2 interferon related developmental regulator 2 SKMc15, SM15, IFNRP 3p21.31
INF2 inverted formin, FH2 and WH2 domain containing C14orf151, C14orf173 MGC13251 14q32.33
INSC INSC, spindle orientation adaptor protein 11p15.2
INTS1 integrator complex subunit 1 DKFZp586J0619, KIAA1440, INT1, NET28 7p22.3
INTS4 integrator complex subunit 4 INT4, MGC16733, MST093 11q14.1
INTS5 integrator complex subunit 5 KIAA1698 INT5 11q12.3
INTS7 integrator complex subunit 7 C1orf73 DKFZP434B168, INT7 1q32.3
IQCB1 IQ motif containing B1 KIAA0036, NPHP5, SLSN5 3q13.33
KIAA0825 KIAA0825 C5orf36 DKFZp686F0372, MGC34713 5q15
RELCH RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing KIAA1468 HsT885, HsT3308, FLJ33841 18q21.33
KIFAP3 kinesin associated protein 3 SMAP, KAP3, FLA3, KAP-1 1q24.2
LRBA LPS responsive beige-like anchor protein CDC4L BGL, LAB300, LBA 4q31.3
LRRK2 leucine rich repeat kinase 2 PARK8 ROCO2, DKFZp434H2111, FLJ45829, RIPK7 12q12
LTN1 listerin E3 ubiquitin protein ligase 1 C21orf98, C21orf10, ZNF294, RNF160 KIAA0714, FLJ11053, LISTERIN 21q21.3
MAPK7 mitogen-activated protein kinase 7 PRKM7 BMK1, ERK5 17p11.2
MEI1 meiotic double-stranded break formation protein 1 MGC40042, SPATA38 22q13.2
MINK1 misshapen like kinase 1 B55, MINK, ZC3, MAP4K6, YSK2 17p13.2
MMS19 MMS19 homolog, cytosolic iron-sulfur assembly component MMS19L MET18, hMMS19, CIAO4 10q24.1
MON2 MON2 homolog, regulator of endosome-to-Golgi trafficking KIAA1040 12q14.1
MTOR mechanistic target of rapamycin kinase FRAP, FRAP2, FRAP1 RAFT1, RAPT1, FLJ44809 1p36.22
MYBBP1A MYB binding protein 1a P160, PAP2, FLJ37886, Pol5 17p13.2
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit NARG1 TBDN100, NATH, FLJ13340 4q31.1
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit NARG1L FLJ22054, MGC40612, PRO2435 13q14.11
NBEA neurobeachin KIAA1544, BCL8B, FLJ10197, LYST2 13q13.3
NBEAL1 neurobeachin like 1 ALS2CR17, ALS2CR16 MGC164581 2q33.2
NBEAL2 neurobeachin like 2 KIAA0540 3p21.31
NCAPD2 non-SMC condensin I complex subunit D2 CNAP1, hCAP-D2, CAP-D2, KIAA0159 12p13.31
NCAPD3 non-SMC condensin II complex subunit D3 hCAP-D3, CAP-D3, hHCP-6, KIAA0056, FLJ42888, hcp-6 11q25
NCAPG non-SMC condensin I complex subunit G FLJ12450, hCAP-G, CAP-G, YCG1 4p15.31
NCAPG2 non-SMC condensin II complex subunit G2 LUZP5 FLJ20311, MTB, CAP-G2, hCAP-G2 7q36.3
NCDN neurochondrin NCDN-1, NCDN-2 1p34.3
NEK10 NIMA related kinase 10 FLJ32685 3p24.1
NELFCD negative elongation factor complex member C/D TH1L HSPC130, TH1, NELF-C, NELF-D 20q13.32
NF1 neurofibromin 1 17q11.2
NIPBL NIPBL, cohesin loading factor IDN3, DKFZp434L1319, FLJ11203, FLJ12597, FLJ13354, FLJ13648, Scc2 5p13.2
NOC2L NOC2 like nucleolar associated transcriptional repressor DKFZP564C186, NET7, NET15, NIR, PPP1R112 1p36.33
NOC3L NOC3 like DNA replication regulator C10orf117 AD24, FLJ12820, FAD24 10q23.33
NOC4L nucleolar complex associated 4 homolog MGC3162, NET49, UTP19, Noc4 12q24.33
NOP9 NOP9 nucleolar protein C14orf21 14q12
NUP188 nucleoporin 188 KIAA0169 9q34.11
NUP205 nucleoporin 205 C7orf14 KIAA0225 7q33
PACRG parkin coregulated PARK2CRG, FLJ32724, Glup, HAK005771 6q26
PACRGL parkin coregulated like C4orf28 MGC29898 4p15.31
PATL2 PAT1 homolog 2 Pat1a 15q21.1
PDS5A PDS5 cohesin associated factor A KIAA0648, PIG54, SCC-112 4p14
PDS5B PDS5 cohesin associated factor B APRIN AS3, KIAA0979, FLJ23236, CG008 13q13.1
PELP1 proline, glutamate and leucine rich protein 1 MNAR 17p13.2
PIEZO2 piezo type mechanosensitive ion channel component 2 FAM38B2, C18orf30, C18orf58, FAM38B FLJ23403, FLJ23144, HsT748, HsT771, FLJ34907 18p11.22-p11.21
PIK3R4 phosphoinositide-3-kinase regulatory subunit 4 VPS15, p150 3q22.1
PI4KA phosphatidylinositol 4-kinase alpha PIK4CA PI4K-ALPHA, pi4K230 22q11.21
PLAA phospholipase A2 activating protein PLAP, PLA2P, FLJ11281, FLJ12699, DOA1 9p21.2
PPP2R1A protein phosphatase 2 scaffold subunit Aalpha PR65A, PP2A-Aalpha, PP2AA 19q13.41
PPP2R1B protein phosphatase 2 scaffold subunit Abeta PR65B, PP2A-Abeta 11q23.1
PPP2R5A protein phosphatase 2 regulatory subunit B'alpha PR61A, B56A, B56alpha 1q32.3
PPP2R5B protein phosphatase 2 regulatory subunit B'beta FLJ35411, B56B, PR61B, B56beta 11q13.1
PPP2R5C protein phosphatase 2 regulatory subunit B'gamma B56G, PR61G, B56gamma 14q32.31
PPP2R5D protein phosphatase 2 regulatory subunit B'delta B56D, B56delta 6p21.1
PPP2R5E protein phosphatase 2 regulatory subunit B'epsilon B56E, B56epsilon 14q23.2
PPP4R1 protein phosphatase 4 regulatory subunit 1 PP4R1 18p11.22
PPP4R1L protein phosphatase 4 regulatory subunit 1 like (pseudogene) C20orf192 bA196N14.4, bA196N14.5, PPP4R1P1 20q13.32
PPP4R3A protein phosphatase 4 regulatory subunit 3A KIAA2010, SMEK1 FLJ20707, MSTP033, FLFL1, smk-1, smk1, PP4R3 14q32.12
PPP4R3B protein phosphatase 4 regulatory subunit 3B SMEK2 PSY2, FLFL2, KIAA1387, FLJ31474 2p16.1
PPP4R3C protein phosphatase 4 regulatory subunit 3C SMEK3P, PPP4R3CP FLJ32867, FLFL3P, smk1 Xp21.3
PPP4R4 protein phosphatase 4 regulatory subunit 4 KIAA1622 PP4R4, CFAP14 14q32.2
PPP6R2 protein phosphatase 6 regulatory subunit 2 KIAA0685, SAPS2 dJ579N16.1, SAP190 22q13.33
PPP6R3 protein phosphatase 6 regulatory subunit 3 C11orf23, SAPS3 SAPLa, DKFZp781E2374, DKFZp781O2362, DKFZp781E17107, SAP190, SAPL, PP6R3, FLJ11058, FLJ43065, KIAA1558, MGC125711, MGC125712 11q13
PRKDC protein kinase, DNA-activated, catalytic subunit HYRC, HYRC1 DNPK1, p350, DNAPK, XRCC7, DNA-PKcs, DNAPKc, DNA-PKC, p460 8q11.21
PSMD1 proteasome 26S subunit, non-ATPase 1 S1, P112, Rpn2 2q37.1
PSMD2 proteasome 26S subunit, non-ATPase 2 S2, P97, TRAP2, MGC14274, Rpn1 3q27.1
PSMD5 proteasome 26S subunit, non-ATPase 5 S5B, KIAA0072 9q33.2
PSME4 proteasome activator subunit 4 PA200, KIAA0077 2p16.2
RALGAPA2 Ral GTPase activating protein catalytic alpha subunit 2 C20orf74 dJ1049G11.4, AS250, KIAA1272, RapGAPalpha2 20p11.23
RALGAPB Ral GTPase activating protein non-catalytic beta subunit KIAA1219 DKFZp781M2411, RalGAPbeta 20q11.23
RANBP6 RAN binding protein 6 9p24.1
RANBP17 RAN binding protein 17 5q35.1
RICTOR RPTOR independent companion of MTOR complex 2 MGC39830, AVO3, PIA, KIAA1999 5p13.1
RIC8A RIC8 guanine nucleotide exchange factor A synembryn, synembryn-A 11p15.5
RIC8B RIC8 guanine nucleotide exchange factor B FLJ10620, hSyn, RIC8 12q23.3
RIF1 replication timing regulatory factor 1 FLJ12870, FLJ10599 2q23.3
RIPOR1 RHO family interacting cell polarization regulator 1 FAM65A FLJ13725 16q22.1
RIPOR2 RHO family interacting cell polarization regulator 2 C6orf32, FAM65B KIAA0386, DIFF48, MYONAP 6p22.3
RNF123 ring finger protein 123 FLJ12565, KPC1 3p21.31
RPTOR regulatory associated protein of MTOR complex 1 KOG1, Mip1, KIAA1303, raptor 17q25.3
RRN3 RRN3 homolog, RNA polymerase I transcription factor DKFZp566E104, TIF-IA 16p13.11
RRP12 ribosomal RNA processing 12 homolog KIAA0690 10q24.1
RSPH14 radial spoke head 14 homolog RTDR1 22q11.22-q11.23
RTTN rotatin DKFZP434G145 18q22.1
RYR2 ryanodine receptor 2 ARVD2 ARVC2, VTSIP 1q43
SAAL1 serum amyloid A like 1 FLJ41463 11p15.1
SAMD4A sterile alpha motif domain containing 4A SAMD4 KIAA1053, DKFZP434H0350, Smaug, SMG, SMGA, hSmaug1 14q22.2
SAMD4B sterile alpha motif domain containing 4B FLJ10211, MGC99832, SMGB, hSmaug2 19q13.2
SARM1 sterile alpha and TIR motif containing 1 SARM, SAMD2, KIAA0524 17q11.2
SCYL1 SCY1 like pseudokinase 1 NTKL HT019, P105, GKLP, NKTL, TAPK, TRAP, TEIF, MGC78454 11q13.1
SCYL2 SCY1 like pseudokinase 2 KIAA1360, CVAK104 12q23.1
SDAD1 SDA1 domain containing 1 FLJ10498 4q21.1
SERAC1 serine active site containing 1 FLJ14917 6q25.3
SF3B1 splicing factor 3b subunit 1 SAP155, SF3b155, PRPF10, Prp10, Hsh155 2q33.1
SF3B2 splicing factor 3b subunit 2 SAP145, SF3b1, Cus1, SF3b145 11q13.1
SIL1 SIL1 nucleotide exchange factor MSS BAP, ULG5 5q31.2
SMG1 SMG1, nonsense mediated mRNA decay associated PI3K related kinase LIP, KIAA0421, ATX 16p12.3
STAG1 stromal antigen 1 SA-1, SCC3A, SA1 3q22.3
STAG2 stromal antigen 2 SA-2, SCC3B, SA2 Xq25
STAG3 stromal antigen 3 7q22.1
STAG3L1 stromal antigen 3-like 1 (pseudogene) DKFZP434A0131, STAG3L1P 7q11.23
STAG3L2 stromal antigen 3-like 2 (pseudogene) MGC131759, STAG3L2P 7q11.23
STAG3L3 stromal antigen 3-like 3 (pseudogene) STAG3L3P 7q11.23
STK36 serine/threonine kinase 36 KIAA1278, FU 2q35
SUPT16H SPT16 homolog, facilitates chromatin remodeling subunit FACT, FACTP140, SPT16/CDC68, FLJ14010, FLJ10857, CDC68 14q11.2
SYMPK symplekin SYM, SPK 19q13.32
TAF3 TATA-box binding protein associated factor 3 TAF140, TAFII140 10p14
TAF6 TATA-box binding protein associated factor 6 TAF2E TAFII70, TAFII80, MGC:8964, TAFII85 7q22.1
TANGO6 transport and golgi organization 6 homolog TMCO7 FLJ12688, KIAA1746 16q22.1
TARBP1 TAR (HIV-1) RNA binding protein 1 TRP-185, TRM3, TRMT3 1q42.2
TBCD tubulin folding cofactor D 17q25.3
TBC1D32 TBC1 domain family member 32 C6orf171, C6orf170 FLJ30899, dJ310J6.1, FLJ34235, bA57L9.1, BROMI 6q22.31
TELO2 telomere maintenance 2 KIAA0683, hCLK2, TEL2 16p13.3
TERB1 telomere repeat binding bouquet formation protein 1 CCDC79 FLJ35894 16q22.1
TEX10 testis expressed 10 FLJ20287, bA208F1.2, Ipi1 9q31.1
TMCO6 transmembrane and coiled-coil domains 6 FLJ39769, PRO1580 5q31.3
TNPO1 transportin 1 KPNB2 MIP, TRN, IPO2, MIP1 5q13.2
TNPO2 transportin 2 IPO3, KPNB2B, FLJ12155, TRN2 19p13.13
TNPO3 transportin 3 LGMD1F TRN-SR, MTR10A, TRN-SR2, IPO12 7q32.1
TNRC6B trinucleotide repeat containing 6B KIAA1093 22q13.1
TRIP12 thyroid hormone receptor interactor 12 KIAA0045 2q36.3
TRPC4AP transient receptor potential cation channel subfamily C member 4 associated protein C20orf188 DKFZP727M231, DKFZp586C1223, dJ756N5.2, TRRP4AP, PPP1R158 20q11.22
TRRAP transformation/transcription domain associated protein TR-AP, PAF400, Tra1 7q22.1
TSC1 TSC complex subunit 1 TSC KIAA0243, LAM, hamartin 9q34
TSC2 TSC complex subunit 2 TSC4 tuberin, LAM, PPP1R160 16p13.3
TTBK1 tau tubulin kinase 1 KIAA1855 6p21.1
TTC12 tetratricopeptide repeat domain 12 FLJ13859, FLJ20535, TPARM 11q23.2
TTI1 TELO2 interacting protein 1 KIAA0406 smg-10 20q11.23
TTI2 TELO2 interacting protein 2 C8orf41 FLJ23263 8p12
UBE4A ubiquitination factor E4A UBOX2, UFD2, KIAA0126, E4 11q23.3
UBR4 ubiquitin protein ligase E3 component n-recognin 4 ZUBR1 KIAA1307, KIAA0462, RBAF600 1p36.13
ULK4 unc-51 like kinase 4 FLJ20574, REC01035, FAM7C1 3p22.1
UNC45A unc-45 myosin chaperone A SMAP-1, GC-UNC45 15q26.1
UNC45B unc-45 myosin chaperone B CMYA4 UNC45 17q12
UNC79 unc-79 homolog, NALCN channel complex subunit KIAA1409 14q32.12
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae) C21orf108 KIAA0539, NPA1 21q22.11
USO1 USO1 vesicle transport factor TAP, VDP, p115 4q21.1
USP9X ubiquitin specific peptidase 9 X-linked DFFRX, FAF, MRX99 Xp11.4
USP9Y ubiquitin specific peptidase 9 Y-linked DFFRY Yq11.221
USP34 ubiquitin specific peptidase 34 KIAA0570, KIAA0729 2p15
UTP20 UTP20, small subunit processome component DRIM, 1A6/DRIM 12q23.2
VAC14 Vac14, PIKFYVE complex component TAX1BP2 FLJ10305, ArPIKfyve 16q22.1-q22.2
VEPH1 ventricular zone expressed PH domain containing 1 FLJ12604, KIAA1692 3q25.31-q25.32
VIRMA vir like m6A methyltransferase associated KIAA1429 DKFZP434I116, fSAP121 8q22.1
VPS35 VPS35, retromer complex component FLJ10752, MEM3, PARK17 16q11.2
WAPL WAPL cohesin release factor KIAA0261, WAPAL FOE 10q23.2
WDFY3 WD repeat and FYVE domain containing 3 KIAA0993, ALFY, ZFYVE25 4q21.23
WDFY4 WDFY family member 4 C10orf64 KIAA1607, Em:AC060234.3, FLJ45748 10q11.23
WDR7 WD repeat domain 7 KIAA0541, TRAG 18q21.31
WDR81 WD repeat domain 81 FLJ33817, PPP1R166, CAMRQ2, SORF-2 17p13.3
WDR87 WD repeat domain 87 NYD-SP11 19q13.13
ZC3H4 zinc finger CCCH-type containing 4 C19orf7 KIAA1064 19q13.33
ZER1 zyg-11 related cell cycle regulator C9orf60, ZYG11BL ZYG, Hzyg 9q34.11
ZYG11A zyg-11 family member A, cell cycle regulator ZYG11 1p32.3
ZYG11B zyg-11 family member B, cell cycle regulator ZYG11 FLJ13456 1p32.3

Genes contained within subsets

Comments

This domain consists of a multi-helical fold comprised of two curved layers of alpha helices arranged in a regular right-handed superhelix, where the repeats that make up this structure are arranged about a common axis [PMID: 10361086]. These superhelical structures present an extensive solvent-accessible surface that is well suited to binding large substrates such as proteins and nucleic acids. This topology has been found with a number of repeats and domains, including the armadillo repeat (found in beta-catenins and importins), the HEAT repeat (found in protein phosphatase 2a and initiation factor eIF4G), the PHAT domain (found in Smaug RNA-binding protein), the leucine-rich repeat variant, the Pumilo repeat, and in the H regulatory subunit of V-type ATPases. The sequence similarity among these different repeats or domains is low, however they exhibit considerable structural similarity. Furthermore, the number of repeats present in the superhelical structure can vary between orthologues, indicating that rapid loss/gain of repeats has occurred frequently in evolution. A common phylogenetic origin has been proposed for the armadillo and HEAT repeats [PMID: 11551174].

Publications

10361086,11551174