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Gene Family: eNoSC complex

Also known as : "energy dependent nucleolar silencing complex"

eNOsc complex:: Glucose deprivation reduces rRNA synthesis. An energy-dependent change in the NAD+/NADH ratio regulates the eNoSC complex, allowing it to couple the changing energy status with the level of rRNA transcription by regulating the epigenetic status of rRNA clusters. eNoSC promotes the restoration of energy balance and protects cells from energy deprivation-induced apoptosis. [Source: Kumazawa et al, 2011]

Genes contained within the family: 3

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
RRP8 ribosomal RNA processing 8 KIAA0409 NML 11p15.4
SIRT1 sirtuin 1 SIR2L1 10q21.3
SUV39H1 suppressor of variegation 3-9 homolog 1 SUV39H KMT1A Xp11.23