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Gene Family: Golgi associated retrograde protein (GARP) complex

Genes contained within the family: 4

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
VPS51 VPS51, GARP complex subunit C11orf3, C11orf2 ANG2, ANG3, FFR 11q13.1
VPS52 VPS52, GARP complex subunit SACM2L ARE1 6p21.32
VPS53 VPS53, GARP complex subunit FLJ10979, HCCS1 17p13.3
VPS54 VPS54, GARP complex subunit HCC8, PPP1R164 2p15-p14


Tethering factors are large protein complexes that capture transport vesicles and enable their fusion with acceptor organelles at different stages of the endomembrane system. The Golgi-associated retrograde protein (GARP) complex is a heterotetrameric tethering factor which promotes fusion of endosome-derived, retrograde transport carriers to the trans-Golgi network (TGN). This complex shares 3 of it's four subunits with another tethering complex, known as the endosome-associated recycling protein (EARP) complex.