Gene Family: Golgi associated retrograde protein (GARP) complex
|Approved Symbol||Approved Name||Previous Symbols||Synonyms||Chromosome|
|VPS51||VPS51, GARP complex subunit||C11orf3, C11orf2||ANG2, ANG3, FFR||11q13.1|
|VPS52||VPS52, GARP complex subunit||SACM2L||ARE1||6p21.32|
|VPS53||VPS53, GARP complex subunit||FLJ10979, HCCS1||17p13.3|
|VPS54||VPS54, GARP complex subunit||HCC8, PPP1R164||2p15-p14|
Tethering factors are large protein complexes that capture transport vesicles and enable their fusion with acceptor organelles at different stages of the endomembrane system. The Golgi-associated retrograde protein (GARP) complex is a heterotetrameric tethering factor which promotes fusion of endosome-derived, retrograde transport carriers to the trans-Golgi network (TGN). This complex shares 3 of it's four subunits with another tethering complex, known as the endosome-associated recycling protein (EARP) complex.