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Gene Family: Endosome-associated recycling protein (EARP) complex

Genes contained within the family: 4

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
VPS50 VPS50, EARP/GARPII complex subunit CCDC132 KIAA1861, FLJ20097, DKFZp313I2429, VPS54L 7q21.2-q21.3
VPS51 VPS51, GARP complex subunit C11orf3, C11orf2 ANG2, ANG3, FFR 11q13.1
VPS52 VPS52, GARP complex subunit SACM2L ARE1 6p21.32
VPS53 VPS53, GARP complex subunit FLJ10979, HCCS1 17p13.3


Recycling through the trans-Golgi network (TGN) and to the plasma membrane is facilitated by the Golgi associated retrograde protein (GARP) and endosome-associated recycling protein (EARP) complexes, respectively. The exchange of the VPS54 subunit in GARP to VPS50 [also known as VESA-1/syndetin] in EARP causes localization of the complex to RAB4-positive recycling endosomes, which promote constitutive recycling of proteins such as the transferrin-receptor.