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Gene Family: SET domain containing (SET)

Family contains the following subsets

Genes contained within the family: 35

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
ASH1L ASH1 like histone lysine methyltransferase huASH1, ASH1, ASH1L1, KMT2H 1q22
EHMT1 euchromatic histone lysine methyltransferase 1 EHMT1-IT1 Eu-HMTase1, FLJ12879, KIAA1876, bA188C12.1, KMT1D, FLJ40292 9q34.3
EHMT2 euchromatic histone lysine methyltransferase 2 C6orf30, BAT8 G9A, Em:AF134726.3, NG36/G9a, KMT1C 6p21.33
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit KIAA0388, KMT6B 17q21.2
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit EZH1, ENX-1, KMT6, KMT6A 7q36.1
KMT2A lysine methyltransferase 2A MLL TRX1, HRX, ALL-1, HTRX1, CXXC7, MLL1A 11q23.3
KMT2B lysine methyltransferase 2B KIAA0304, MLL2, TRX2, HRX2, WBP7, MLL1B, MLL4, CXXC10 19q13.12
KMT2C lysine methyltransferase 2C MLL3 KIAA1506, HALR 7q36.1
KMT2D lysine methyltransferase 2D TNRC21, MLL2 ALR, MLL4, CAGL114 12q13.12
KMT2E lysine methyltransferase 2E MLL5 HDCMC04P 7q22.3
KMT5A lysine methyltransferase 5A SETD8 SET8, SET07, PR-Set7 12q24.31
KMT5C lysine methyltransferase 5C SUV420H2 MGC2705 19q13.42
NSD2 nuclear receptor binding SET domain protein 2 WHSC1 MMSET, KMT3G 4p16.3
NSD3 nuclear receptor binding SET domain protein 3 WHSC1L1 FLJ20353, WHISTLE, KMT3F 8p11.23
SETDB1 SET domain bifurcated 1 KG1T, KIAA0067, ESET, KMT1E, TDRD21 1q21.3
SETDB2 SET domain bifurcated 2 C13orf4 CLLD8, CLLL8, KMT1F 13q14.2
SETD1A SET domain containing 1A KIAA0339, Set1, KMT2F 16p11.2
SETD1B SET domain containing 1B KIAA1076, Set1B, KMT2G 12q24.31
SETD2 SET domain containing 2 HYPB, HIF-1, KIAA1732, FLJ23184, KMT3A 3p21.31
SETD3 SET domain containing 3 C14orf154 FLJ23027 14q32.2
SETD4 SET domain containing 4 C21orf27, C21orf18 21q22.12
SETD5 SET domain containing 5 FLJ10707 3p25.3
SETD6 SET domain containing 6 FLJ21148 16q21
SETD7 SET domain containing lysine methyltransferase 7 KIAA1717, SET7, SET7/9, Set9, KMT7 4q31.1
SETD9 SET domain containing 9 C5orf35 MGC33648 5q11.2
SETMAR SET domain and mariner transposase fusion gene metnase 3p26.1
SMYD1 SET and MYND domain containing 1 BOP, ZMYND22, KMT3D 2p11.2
SMYD2 SET and MYND domain containing 2 HSKM-B, ZMYND14, KMT3C 1q32.3
SMYD3 SET and MYND domain containing 3 ZNFN3A1, ZMYND1 KMT3E 1q44
SMYD4 SET and MYND domain containing 4 KIAA1936, ZMYND21 17p13.3
SMYD5 SMYD family member 5 RAI15 RRG1, NN8-4AG, ZMYND23 2p13.2
SUV39H1 suppressor of variegation 3-9 homolog 1 SUV39H KMT1A Xp11.23
SUV39H2 suppressor of variegation 3-9 homolog 2 FLJ23414, KMT1B 10p13
ZFPM1 zinc finger protein, FOG family member 1 FOG1, FOG, ZNF89A, ZC2HC11A 16q24.2
ZFPM2 zinc finger protein, FOG family member 2 FOG2, hFOG-2, ZNF89B, ZC2HC11B 8q23

Genes contained within subsets


This grouping includes all human genes encoding a SET domain, the majority of which are already included in two other sub groupings, the PR/SET domain containing genes and the lysine methyltransferase family (KMTs). However, as the KMTs are a functional as opposed to domain based grouping, and include one non-SET domain containing methyltransferase (DOT1L), they have not been included as a subset of the SET domain containing group.