Skip to Navigation
New Beta Site!

Please view this page on our new HGNC beta site and let us know what you think via the feedback form.

Gene Family: 5.8S ribosomal RNAs (RNA5-8S)

5.8S ribosomal RNA: In molecular biology the 5.8S ribosomal RNA (5.8S rRNA) is a non-coding RNA component of the large subunit of the eukaryotic ribosome and so plays an important role in protein translation. It is transcribed by RNA polymerase I as part of the 45S precursor that also contains 18S and 28S rRNA. Its function is thought to be in ribosome translocation. It is also known to form covalent linkage to the p53 tumour suppressor protein. [Source: Wikipedia]

Genes contained within the family: 5

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
RNA5-8S1 RNA, 5.8S ribosomal 1 13p12 not on reference assembly
RNA5-8S2 RNA, 5.8S ribosomal 2 14p12 not on reference assembly
RNA5-8S3 RNA, 5.8S ribosomal 3 15p12 not on reference assembly
RNA5-8S4 RNA, 5.8S ribosomal 4 21p12 not on reference assembly
RNA5-8S5 RNA, 5.8S ribosomal 5 RN5-8S1 22p12 not on reference assembly


5.8S rRNAs are processed from 45S pre-RNA. The 45S rRNA genes are present in clusters on 13p12, 14p12, 15p12, 21p12, and 22p12 but due to sequencing difficulties these are not present on the current reference genome. The gene symbols above are representative of one 5.8s rRNA from one 45S rRNA repeat per cluster for each chromosomal location. The number of repeats within each cluster varies between individuals.

Specialist advisors