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Gene Family: Iron (II) and 2-oxoglutarate dependent oxygenases

Also known as : "2OG oxygenases", "2OGXs", "2-Oxoglutarate dependent oxygenases"

Family contains the following subsets

Genes contained within the family: 6

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
HSPBAP1 HSPB1 associated protein 1 FLJ22623, PASS1 3q21.1
JARID2 jumonji and AT-rich interaction domain containing 2 JMJ 6p22.3
JMJD6 jumonji domain containing 6, arginine demethylase and lysine hydroxylase PTDSR PTDSR1, KIAA0585 17q25.1
JMJD7 jumonji domain containing 7 15q15.1
RIOX1 ribosomal oxygenase 1 C14orf169 FLJ21802, NO66, MAPJD, JMJD9 14q24.3
RIOX2 ribosomal oxygenase 2 MINA MINA53, FLJ14393, mdig, NO52, JMJD10 3q11.2

Genes contained within subsets

Comments

JMJD6 is proposed to catalyze both N-methyl argininyl demethylation and lysyl hydroxylation (PMID:25997831) and the RIOX1 and RIOX2 genes encode proteins with both lysine demethylase and ribosomal protein hydroxylase activity.

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Publications

29494239,25997831,26152730