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Gene Family: NineTeen complex

Also known as : "PRP19-CDC5L complex", "PRP19 complex", "PRP19C", "PSO4 core complex", "NTC complex", "PRPF19 complex"

NineTeen Complex: NTC/Prp19C was discovered as a complex that functions in splicing and more specifically during the catalytic activation of the spliceosome. More recent work revealed that NTC/Prp19C plays a role in transcription elongation in Saccharomyces cerevisiae and in genome maintenance in higher eukaryotes. [Source: Chanarat et al, 2013]

Genes contained within the family: 6

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
BCAS2 BCAS2, pre-mRNA processing factor DAM1, SPF27, Snt309 1p13.2
CDC5L cell division cycle 5 like PCDC5RP, hCDC5, CEF1, CDC5 6p21.1
CTNNBL1 catenin beta like 1 C20orf33 FLJ21108, P14L, P14, NAP, NYD-SP19 20q11.23
CWC15 CWC15 spliceosome associated protein homolog C11orf5, HSPC148, Cwf15, AD002 11q21
PLRG1 pleiotropic regulator 1 PRL1, Prp46, PRPF46, Cwc1, TANGO4 4q31.3
PRPF19 pre-mRNA processing factor 19 PRP19 UBOX4, NMP200, PSO4, hPSO4, SNEV 11q12.2


There are two other human spliceosome associated complexes including PRPF19: the PRP19-associated complex and the XAB2 complex (PMID:23742842).