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Gene Family: CST complex

: The CST complex localizes specifically to single-stranded telomeric DNA, including the telomeric overhang. In yeast this complex is involved in chromosome end capping and telomere length regulation. The capping properties of CST may be dispensable in vertebrates in vivo due to the presence of the shelterin complex, which also caps chromosome ends. There is evidence to suggest that the CST complex rescues stalled replication forks under conditions of replication stress. [Source: Rice et al]

Genes contained within the family: 3

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
CTC1 CST telomere replication complex component 1 C17orf68 FLJ22170, AAF132 17p13.1
STN1 STN1, CST complex subunit OBFC1 FLJ22559, bA541N10.2 10q24.33
TEN1 TEN1, CST complex subunit C17orf106 FLJ39785 17q25.1

Publications

27239262,27487043,22763445