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Gene Family: SRCAP complex

SRCAP complex: The SRCAP complex remodels chromatin by catalyzing the incorporation of H2AZ-H2B dimers into nucleosomes. The SRCAP complex also plays a role in DSB resection and HR, hence contributing to cell survival upon exposure to DNA damage-inducing agents. [Source: Dong et al, 2014]

Genes contained within the family: 9

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
ACTL6A actin like 6A Actl6, BAF53A, Arp4, Baf53a, INO80K 3q26.33
ACTR6 ARP6 actin related protein 6 homolog ARP6, FLJ13433 12q23.1
DMAP1 DNA methyltransferase 1 associated protein 1 DNMAP1, FLJ11543, KIAA1425, DNMTAP1, EAF2, MEAF2, SWC4 1p34.1
RUVBL1 RuvB like AAA ATPase 1 TIP49, NMP238, RVB1, TIP49a, Pontin52, ECP54, TIH1, Rvb1, INO80H 3q21.3
RUVBL2 RuvB like AAA ATPase 2 RVB2, TIP48, TIP49b, Reptin52, ECP51, TIH2, INO80J, Rvb2 19q13.33
SRCAP Snf2 related CREBBP activator protein KIAA0309, EAF1, SWR1, DOMO1 16p11.2
VPS72 vacuolar protein sorting 72 homolog TCFL1 YL-1, YL1, Swc2 1q21.3
YEATS4 YEATS domain containing 4 NuBI-1, GAS41, YAF9 12q15
ZNHIT1 zinc finger HIT-type containing 1 ZNFN4A1 CG1I, H_DJ0747G18.14 7q22.1

Publications

26974126,26974124,25176633,23122415