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Gene Family: Super elongation complex

Also known as : "SEC"

Super Elongation complex: The super elongation complex (SEC) consists of the RNA polymerase II (Pol II) elongation factors eleven-nineteen Lys-rich leukaemia (ELL) proteins, positive transcription elongation factor b (P-TEFb) and several frequent mixed lineage leukaemia (MLL) translocation partners. It is one of the most active P-TEFb-containing complexes required for rapid transcriptional induction in the presence or absence of paused Pol II. The SEC was found to regulate the transcriptional elongation checkpoint control (TECC) stage of transcription, and misregulation of this stage is associated with cancer pathogenesis. [Source: Luo et al, 2012]

Family contains the following subsets

Genes contained within the family: 9

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
AFF1 AF4/FMR2 family member 1 PBM1, MLLT2 AF-4, AF4 4q21.3-q22.1
AFF2 AF4/FMR2 family member 2 FMR2 FRAXE Xq28
AFF3 AF4/FMR2 family member 3 LAF4 MLLT2-like 2q11.2
AFF4 AF4/FMR2 family member 4 AF5Q31, MCEF 5q31.1
ELL elongation factor for RNA polymerase II C19orf17 Men, ELL1, PPP1R68 19p13.11
ELL2 elongation factor for RNA polymerase II 2 MRCCAT1 5q15
ELL3 elongation factor for RNA polymerase II 3 FLJ22637 15q15.3
MLLT1 MLLT1, super elongation complex subunit ENL, LTG19, YEATS1 19p13.3
MLLT3 MLLT3, super elongation complex subunit AF-9, AF9, YEATS3 9p21.3

Genes contained within subsets