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Gene Family: NF-kappa B complex subunits

Also known as : "NF-kB complex subunits", "NF-kB family", "Rel/NF-kB family"

NF-κB: NF-κB ( nuclear factor kappa-light-chain-enhancer of activated B cells ) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection ( κ light chains are critical components of immunoglobulins). Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory. [Source: Wikipedia]

Genes contained within the family: 5

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
NFKB1 nuclear factor kappa B subunit 1 KBF1, p105, NFKB-p50, p50, NF-kappaB, NFkappaB, NF-kB1 4q24
NFKB2 nuclear factor kappa B subunit 2 LYT-10, p52, p105, NF-kB2, p49/p100 10q24.32
REL REL proto-oncogene, NF-kB subunit I-Rel, c-Rel 2p16.1
RELA RELA proto-oncogene, NF-kB subunit NFKB3 p65 11q13.1
RELB RELB proto-oncogene, NF-kB subunit REL-B 19q13.32